BBX Antibody (G-2): sc-377041
- BBX Antibody (G-2) is a mouse monoclonal IgG1 κ BBX antibody provided at 200 µg/ml
- raised against amino acids 127-210 mapping near the N-terminus of BBX of human origin
- BBX Antibody (G-2) is recommended for detection of BBX of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and canine
- Anti-BBX Antibody (G-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BBX Antibody (G-2) for WB applications. These reagents are now offered in bundles with BBX Antibody (G-2) (see ordering information below).
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SEE ALSO...
BBX Antibody (G-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects BBX protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BBX (G-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BBX protein, also known as HMG box transcription factor BBX or Bobby sox homolog, is a 941 amino acid nuclear protein encoded by the human gene BBX. BBX contains a high mobility group (HMG) domain, which is characteristic of the Sox family of transcription factors. The structural integrity of the HMG domain facilitates BBX binding to DNA, thereby regulating gene expression essential for cell cycle progression from G1 to S phase. BBX function is particularly important in cellular growth and differentiation, and BBX dysregulation has been implicated in various human disorders, including certain cancers and autoimmune diseases. BBX has been associated with the recruitment of inflammatory cells to sites of infection, highlighting BBX role in immune response. The presence of antibodies against HMG proteins, including BBX, is often observed in patients with autoimmune conditions, further underscoring BBX significance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BBX Antibody (G-2) References:
- Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. | Wiemann, S., et al. 2001. Genome Res. 11: 422-35. PMID: 11230166
- HBP2: a new mammalian protein that complements the fission yeast MBF transcription complex. | Sánchez-Díaz, A., et al. 2001. Curr Genet. 40: 110-8. PMID: 11680820
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | Strausberg, RL., et al. 2002. Proc Natl Acad Sci U S A. 99: 16899-903. PMID: 12477932
- Complete sequencing and characterization of 21,243 full-length human cDNAs. | Ota, T., et al. 2004. Nat Genet. 36: 40-5. PMID: 14702039
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
- Difference in the yields of bronchial washing cytology before and after forceps biopsy for lung cancer diagnosis. | Sompradeekul, S., et al. 2006. J Med Assoc Thai. 89 Suppl 5: S37-45. PMID: 17722298
- Bobby Sox homology regulates odontoblast differentiation of human dental pulp stem cells/progenitors. | Choi, YA., et al. 2014. Cell Commun Signal. 12: 35. PMID: 24885382
- NBM-T-BBX-OS01, Semisynthesized from Osthole, Induced G1 Growth Arrest through HDAC6 Inhibition in Lung Cancer Cells. | Pai, JT., et al. 2015. Molecules. 20: 8000-19. PMID: 25946558
- Bobby sox homolog regulates tooth root formation through modulation of dentin sialophosphoprotein. | Ihn, HJ., et al. 2021. J Cell Physiol. 236: 480-488. PMID: 32537777
- Large-scale concatenation cDNA sequencing. | Yu, W., et al. 1997. Genome Res. 7: 353-8. PMID: 9110174
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BBX Antibody (G-2) | sc-377041 | 200 µg/ml | $322.00 | |||
BBX Antibody (G-2): m-IgG Fc BP-HRP Bundle | sc-529962 | 200 µg Ab; 10 µg BP | $361.00 | |||
BBX Antibody (G-2): m-IgGκ BP-HRP Bundle | sc-523166 | 200 µg Ab, 40 µg BP | $361.00 | |||
BBX Antibody (G-2): m-IgG1 BP-HRP Bundle | sc-543792 | 200 µg Ab; 20 µg BP | $361.00 | |||
BBX Antibody (G-2) AC | sc-377041 AC | 500 µg/ml, 25% agarose | $424.00 | |||
BBX Antibody (G-2) HRP | sc-377041 HRP | 200 µg/ml | $322.00 | |||
BBX Antibody (G-2) FITC | sc-377041 FITC | 200 µg/ml | $336.00 | |||
BBX Antibody (G-2) PE | sc-377041 PE | 200 µg/ml | $349.00 | |||
BBX Antibody (G-2) Alexa Fluor® 488 | sc-377041 AF488 | 200 µg/ml | $364.00 | |||
BBX Antibody (G-2) Alexa Fluor® 546 | sc-377041 AF546 | 200 µg/ml | $364.00 | |||
BBX Antibody (G-2) Alexa Fluor® 594 | sc-377041 AF594 | 200 µg/ml | $364.00 | |||
BBX Antibody (G-2) Alexa Fluor® 647 | sc-377041 AF647 | 200 µg/ml | $364.00 | |||
BBX Antibody (G-2) Alexa Fluor® 680 | sc-377041 AF680 | 200 µg/ml | $364.00 | |||
BBX Antibody (G-2) Alexa Fluor® 790 | sc-377041 AF790 | 200 µg/ml | $364.00 |