Bax Antibody (SPM336): sc-65532

Bax Antibody (SPM336) is a mouse monoclonal IgG1 antibody that detects Bax in mouse, rat, human, and primate samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Bax is a critical pro-apoptotic protein that plays a vital role in regulating apoptosis, or programmed cell death, which maintains cellular homeostasis and eliminates damaged or unwanted cells. The balance between Bax and anti-apoptotic Bcl-2 is crucial in determining cell fate; increased Bax levels can promote apoptosis, particularly in response to stress signals or growth factor withdrawal. Bax is primarily localized to the outer mitochondrial membrane, where Bax facilitates cytochrome c release, a key step in the apoptotic pathway. This localization underscores mitochondria′s role as central regulators of apoptosis, and alterations in Bax expression or function can lead to various diseases, including cancer, where evasion of apoptosis is a hallmark. Bax (SPM336) antibody serves as an invaluable tool for researchers studying apoptosis mechanisms and the intricate balance of pro- and anti-apoptotic signals in various biological contexts.

The preferred Bax antibody is Bax Antibody (B-9): sc-7480.