Basic Cytokeratin Antibody (3G129): sc-70402

Basic Cytokeratin Antibody (3G129) is a mouse monoclonal IgG1 antibody that detects Basic Cytokeratin in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Anti-Basic Cytokeratin antibody (3G129) specifically targets type II cytokeratins, which are essential for the structural integrity and function of epithelial cells. Basic Cytokeratin (3G129) antibody recognizes proteins primarily located in the cytoplasm of epithelial cells, where they form intermediate filaments that provide mechanical support and resilience against stress. Basic cytokeratins play a crucial role during epithelial tissue differentiation, as they pair with acidic cytokeratins to form stable filamentous networks that contribute to the overall tissue architecture. This structural role is particularly important in maintaining the integrity of tissues subjected to mechanical forces, such as the skin and the lining of internal organs. Basic Cytokeratin monoclonal antibody (3G129) serves as a valuable tool in cancer research, as alterations in cytokeratin expression can indicate the origin of metastatic tumors, aiding in diagnosis and treatment strategies.

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Basic Cytokeratin Antibody (3G129) References:

1. Corneal epithelial-specific cytokeratin 3 is an autoantigen in Wegener's granulomatosis-associated peripheral ulcerative keratitis.  |  Reynolds, I., et al. 1999. Invest Ophthalmol Vis Sci. 40: 2147-51. PMID: 10440272
2. Cytokeratin expression in chondroblastomas.  |  Semmelink, HJ., et al. 1990. Histopathology. 16: 257-63. PMID: 1692005
3. Molecular milestones that signal axonal maturation and the commitment of human spinal cord precursor cells to the neuronal or glial phenotype in development.  |  Tohyama, T., et al. 1991. J Comp Neurol. 310: 285-99. PMID: 1787174
4. Immunohistochemical findings in primary fallopian tube cancer. Case report.  |  Raba, G., et al. 2010. Eur J Gynaecol Oncol. 31: 120-2. PMID: 20349798
5. Monoclonal cytokeratin antibody recognizing a heterotypic complex: immunological probing of conformational states of cytoskeletal proteins in filaments and in solution.  |  Franke, WW., et al. 1987. Exp Cell Res. 173: 17-37. PMID: 2445593
6. Disruption of the cytokeratin filament network in the preimplantation mouse embryo.  |  Emerson, JA. 1988. Development. 104: 219-34. PMID: 2474425
7. Cytokeratin-positive folliculo-stellate cells in chicken adenohypophysis.  |  Nishimura, S., et al. 2017. Anim Sci J. 88: 1835-1841. PMID: 28699196
8. Differential expression of intermediate filament proteins in metastatic and nonmetastatic variants of the BSp73 tumor.  |  Ben-Ze'ev, A., et al. 1986. Cancer Res. 46: 785-90. PMID: 3940642
9. Cytokeratins of normal epithelia and some neoplasms of the female genital tract.  |  Moll, R., et al. 1983. Lab Invest. 49: 599-610. PMID: 6195450
10. Detection of a cytokeratin determinant common to diverse epithelial cells by a broadly cross-reacting monoclonal antibody.  |  Gigi, O., et al. 1982. EMBO J. 1: 1429-37. PMID: 6202509
11. Cytokeratins in normal lung and lung carcinomas. I. Adenocarcinomas, squamous cell carcinomas and cultured cell lines.  |  Blobel, GA., et al. 1984. Virchows Arch B Cell Pathol Incl Mol Pathol. 45: 407-29. PMID: 6203212
12. A subfamily of relatively large and basic cytokeratin polypeptides as defined by peptide mapping is represented by one or several polypeptides in epithelial cells.  |  Schiller, DL., et al. 1982. EMBO J. 1: 761-9. PMID: 6203737

The preferred Basic Cytokeratin antibody is Basic Cytokeratin Antibody (AE3): sc-57004.