BAP31 Antibody (CC-4): sc-56008
- BAP31 Antibody (CC-4) is a rat monoclonal IgG2a provided at 200 µg/ml
- epitope mapping at amino acids 123-229 of BAP31 of human origin
- recommended for detection of BAP31 of and human origin by WB, IP, IF and IHC(P)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BAP31 Antibody (CC-4). This work is in progress.
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BAP31 Antibody (CC-4) is a rat monoclonal IgG2a antibody that detects BAP31 in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. BAP31 is a crucial integral membrane protein located in the endoplasmic reticulum, where BAP31 plays a significant role in apoptosis regulation. BAP31 forms a protein complex that connects initiator caspases, such as procaspase-8, with anti-apoptotic proteins like Bcl-2 and Bcl-XL, thereby influencing cell survival and death pathways. The cytosolic domain of BAP31 features two identical caspase recognition sites, which are specifically cleaved by initiator caspases during apoptosis, resulting in the generation of a p20 fragment that remains membrane-integrated and acts as a potent inducer of cell death when ectopically expressed. This cleavage is vital for triggering cytoplasmic apoptotic events, including membrane fragmentation, and facilitates the interaction between mitochondria and the endoplasmic reticulum during Fas-mediated apoptosis. The BAP31 gene is widely expressed across murine tissues and is located on the X chromosome in both mice and humans, underscoring BAP31′s importance in cellular processes and potential implications in various diseases.
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BAP31 Antibody (CC-4) References:
- BAP31 is involved in T cell activation through TCR signal pathways. | Niu, K., et al. 2017. Sci Rep. 7: 44809. PMID: 28333124
- A BAP31 intrabody induces gastric cancer cell death by inhibiting p27kip1 proteasome degradation. | Chen, J., et al. 2019. Int J Cancer. 144: 2051-2062. PMID: 30338855
- MiR-451a suppressing BAP31 can inhibit proliferation and increase apoptosis through inducing ER stress in colorectal cancer. | Xu, K., et al. 2019. Cell Death Dis. 10: 152. PMID: 30770794
- BAP31 Promotes Tumor Cell Proliferation by Stabilizing SERPINE2 in Hepatocellular Carcinoma. | Zhang, X., et al. 2020. Front Cell Dev Biol. 8: 607906. PMID: 33363167
- Regulation of Superoxide by BAP31 through Its Effect on p22phox and Keap1/Nrf2/HO-1 Signaling Pathway in Microglia. | Liu, X., et al. 2021. Oxid Med Cell Longev. 2021: 1457089. PMID: 33777312
- Hepatocyte-Specific Deficiency of BAP31 Amplified Acetaminophen-Induced Hepatotoxicity via Attenuating Nrf2 Signaling Activation in Mice. | Zhao, J., et al. 2021. Int J Mol Sci. 22: PMID: 34639126
- BAP31 regulates the expression of ICAM-1/VCAM-1 via MyD88/NF-κB pathway in acute lung injury mice model. | Li, G., et al. 2023. Life Sci. 313: 121310. PMID: 36549351
- The BAP31/miR-181a-5p/RECK axis promotes angiogenesis in colorectal cancer via fibroblast activation. | Zhang, Q., et al. 2023. Front Oncol. 13: 1056903. PMID: 36895489
- Knockdown of BAP31 Downregulates Galectin-3 to Inhibit the Wnt/β-Catenin Signaling Pathway to Modulate 5-FU Chemosensitivity and Cancer Stemness in Colorectal Cancer. | Liu, J., et al. 2023. Int J Mol Sci. 24: PMID: 37762705
- BAP31 Plays an Essential Role in Mouse B Cell Development via Regulation of BCR Signaling. | Zhao, B., et al. 2024. Int J Mol Sci. 25: PMID: 38732181
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAP31 Antibody (CC-4) | sc-56008 | 200 µg/ml | $322.00 |