BAP31 Antibody (CC-1): sc-56007
- BAP31 Antibody (CC-1) is a rat monoclonal IgG2a, cited in 1 publications, provided at 200 µg/ml
- epitope mapping at amino acids 230-246 of BAP31 of human origin
- recommended for detection of BAP31 of mouse, rat and human origin by WB, IP and IF; also reactive with additional species, including bovine
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for BAP31 Antibody (CC-1). This work is in progress.
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BAP31 Antibody (CC-1) is a rat monoclonal IgG2a antibody that detects BAP31 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). BAP31 is a crucial integral membrane protein located in the endoplasmic reticulum, where BAP31 plays a significant role in apoptosis regulation. BAP31 forms a protein complex that connects apoptosis-initiating caspases, like procaspase-8, with anti-apoptotic regulators such as Bcl-2 and Bcl-XL, thereby influencing cell survival and death pathways. The cytosolic domain of BAP31 features two identical caspase recognition sites, which are specifically cleaved by initiator caspases, leading to the generation of a p20 fragment during apoptosis. This fragment remains embedded in the membrane and has been shown to be a potent inducer of cell death when ectopically expressed. The cleavage of BAP31 is vital for triggering cytoplasmic apoptotic events, including membrane fragmentation, and facilitates the interaction between mitochondria and the endoplasmic reticulum during Fas-mediated apoptosis. The BAP31 gene is ubiquitously expressed across murine tissues and is located on the X chromosome in both mice and humans, highlighting BAP31′s evolutionary conservation and importance in cellular processes. Anti-BAP31 antibody (CC-1) is an essential tool for researchers studying apoptosis and related signaling pathways.
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BAP31 Antibody (CC-1) References:
- BAP31 regulates IRAK1-dependent neuroinflammation in microglia. | Liu, X., et al. 2019. J Neuroinflammation. 16: 281. PMID: 31883536
- BAP31 Regulates Wnt Signaling to Modulate Cell Migration in Lung Cancer. | Li, T., et al. 2022. Front Oncol. 12: 859195. PMID: 35359416
- BAP31 affects macrophage polarization through regulating helper T cells activation. | Yuan, Q., et al. 2022. J Mol Histol. 53: 843-855. PMID: 36018529
- BAP31 depletion inhibited adipogenesis, repressed lipolysis and promoted lipid droplets abnormal growth via attenuating Perilipin1 proteasomal degradation. | Wei, X., et al. 2023. Int J Biol Sci. 19: 1713-1730. PMID: 37063427
- Knockdown of BAP31 Overcomes Hepatocellular Carcinoma Doxorubicin Resistance through Downregulation of Survivin. | Liu, J., et al. 2023. Int J Mol Sci. 24: PMID: 37108785
- HNF4A-BAP31-VDAC1 axis synchronously regulates cell proliferation and ferroptosis in gastric cancer. | Zhou, Q., et al. 2023. Cell Death Dis. 14: 356. PMID: 37296105
- BAP31 Knockout in Macrophages Affects CD4+T Cell Activation through Upregulation of MHC Class II Molecule. | Zhao, B., et al. 2023. Int J Mol Sci. 24: PMID: 37686286
- BAP31-Mediated miR-206/133b Cluster Promotes Transendothelial Migration and Metastasis of Colorectal Cancer. | Zhang, Q., et al. 2023. Int J Mol Sci. 24: PMID: 38069061
- BAP31 Promotes Adhesion Between Endothelial Cells and Macrophages Through the NF-κB Signaling Pathway in Sepsis. | He, J., et al. 2024. J Inflamm Res. 17: 1267-1279. PMID: 38434584
- BAP31 Promotes Angiogenesis via Galectin-3 Upregulation in Neuroblastoma. | Namusamba, M., et al. 2024. Int J Mol Sci. 25: PMID: 38474195
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAP31 Antibody (CC-1) | sc-56007 | 200 µg/ml | $322.00 |