BAP1 Antibody (F-6): sc-48386
- BAP1 Antibody (F-6) is a mouse monoclonal IgG2a κ, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 430-729 of BAP1 of human origin
- recommended for detection of BAP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- See BAP1 (C-4): sc-28383 for BAP1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for BAP1 Antibody (F-6) for WB applications. These reagents are now offered in bundles with BAP1 Antibody (F-6) (see ordering information below).
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BAP1 Antibody (F-6) is a mouse monoclonal IgG2a antibody that detects BAP1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAP1, or BRCA1-associated protein 1, is a crucial protein that functions as a ubiquitin hydrolase, playing a significant role in the regulation of protein degradation and cellular signaling pathways. This function is vital for maintaining cellular homeostasis and preventing tumorigenesis, as BAP1 helps to modulate the activity of various substrates involved in cell cycle regulation and DNA repair. The interaction of BAP1 with BRCA1 is particularly important, as BAP1 enhances BRCA1-mediated cell growth suppression, thereby contributing to the tumor-suppressive functions of the BRCA1-BAP1 complex. Additionally, BAP1 interacts with several other proteins, including the histone deubiquitinase complex, which further underscores BAP1′s role in epigenetic regulation and cancer biology. Anti-BAP1 antibody (F-6) is an essential tool for researchers studying the mechanisms of cancer development and the intricate pathways involved in tumor suppression.
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LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
BAP1 Antibody (F-6) References:
- BAP1, a tumor suppressor gene driving malignant mesothelioma. | Cheung, M. and Testa, JR. 2017. Transl Lung Cancer Res. 6: 270-278. PMID: 28713672
- BAP1-Mutated Clear Cell Renal Cell Carcinoma. | Gallan, AJ., et al. 2021. Am J Clin Pathol. 155: 718-728. PMID: 33210135
- Roles of the BAP1 Tumor Suppressor in Cell Metabolism. | Han, A., et al. 2021. Cancer Res. 81: 2807-2814. PMID: 33446574
- Emerging multifaceted roles of BAP1 complexes in biological processes. | Szczepanski, AP. and Wang, L. 2021. Cell Death Discov. 7: 20. PMID: 33483476
- Medical and Surgical Care of Patients With Mesothelioma and Their Relatives Carrying Germline BAP1 Mutations. | Carbone, M., et al. 2022. J Thorac Oncol. 17: 873-889. PMID: 35462085
- The expanding role of BAP1 in clear cell renal cell carcinoma. | Kapur, P., et al. 2023. Hum Pathol. 133: 22-31. PMID: 35932824
- BAP1 loss induces mitotic defects in mesothelioma cells through BRCA1-dependent and independent mechanisms. | Singh, A., et al. 2023. Oncogene. 42: 572-585. PMID: 36550359
- Structural basis of histone H2A lysine 119 deubiquitination by Polycomb repressive deubiquitinase BAP1/ASXL1. | Thomas, JF., et al. 2023. Sci Adv. 9: eadg9832. PMID: 37556531
- BAP1 is required prenatally for differentiation and maintenance of postnatal murine enteric nervous system. | Schneider, S., et al. 2024. J Clin Invest. 134: PMID: 38690732
- BAP1 regulates HSF1 activity and cancer immunity in pancreatic cancer. | Yuan, W., et al. 2024. J Exp Clin Cancer Res. 43: 275. PMID: 39350280
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
BAP1 Antibody (F-6) | sc-48386 | 200 µg/ml | $322.00 | |||
BAP1 Antibody (F-6): m-IgG Fc BP-HRP Bundle | sc-536823 | 200 µg Ab; 10 µg BP | $361.00 | |||
BAP1 Antibody (F-6): m-IgGκ BP-HRP Bundle | sc-533990 | 200 µg Ab; 40 µg BP | $361.00 | |||
BAP1 Antibody (F-6): m-IgG2a BP-HRP Bundle | sc-547877 | 200 µg Ab; 10 µg BP | $361.00 |