BAIAP2L1 Antibody (F-9): sc-393838

BAIAP2L1 Antibody (F-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects BAIAP2L1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-BAIAP2L1 antibody (F-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BAIAP2L1, also known as Brain-specific angiogenesis inhibitor 1-associated protein 2-like 1 or IRTKS (insulin receptor tyrosine kinase substrate), is a 511 amino acid protein predominantly expressed in liver, testis, bladder, lung, and heart. BAIAP2L1 plays a crucial role in cellular dynamics, particularly in actin cytoskeleton organization, containing an IMD (IRSp53/MTSS1 homology) domain, an SH3 domain, and a C-terminal region similar to a WH2 domain. BAIAP2L1 is involved in forming short actin clusters at cell periphery, contrasting with filopodia-like protrusions induced by IRSp53. BAIAP2L1 binds Rac through N-terminal IMD domain and serves as a substrate for insulin receptor, leading to tyrosine phosphorylation upon insulin stimulation, highlighting BAIAP2L1′s significance in cellular signaling pathways and actin dynamics.

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BAIAP2L1 Antibody (F-9) References:

1. Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53.  |  Millard, TH., et al. 2005. EMBO J. 24: 240-50. PMID: 15635447
2. The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation.  |  Suetsugu, S., et al. 2006. J Biol Chem. 281: 35347-58. PMID: 17003044
3. Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.  |  Disanza, A., et al. 2006. Nat Cell Biol. 8: 1337-47. PMID: 17115031
4. Structural basis for the actin-binding function of missing-in-metastasis.  |  Lee, SH., et al. 2007. Structure. 15: 145-55. PMID: 17292833
5. Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism.  |  Mattila, PK., et al. 2007. J Cell Biol. 176: 953-64. PMID: 17371834
6. Characterisation of IRTKS, a novel IRSp53/MIM family actin regulator with distinct filament bundling properties.  |  Millard, TH., et al. 2007. J Cell Sci. 120: 1663-72. PMID: 17430976
7. Distinctive gene expression signatures in rheumatoid arthritis synovial tissue fibroblast cells: correlates with disease activity.  |  Galligan, CL., et al. 2007. Genes Immun. 8: 480-91. PMID: 17568789
8. Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase.  |  Yeh, TC., et al. 1996. J Biol Chem. 271: 2921-8. PMID: 8621681

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BAIAP2L1 Antibody (F-9) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-BAIAP2L1 Antibody (F-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BAIAP2L1 Antibody (F-9) Specifications

Alternate Product Name: BAIAP2L1

Product Clone Name: F-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 213-357

Epitope Target: BAIAP2L1

Epitope Species: human

Product Reactivity/Detection: BAIAP2L1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for BAIAP2L1 Antibody (F-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin