Bag-1 Antibody (A-4): sc-377419
- Bag-1 Antibody (A-4) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 117-155 within an internal region of Bag-1 of human origin
- recommended for detection of Bag-1 of mouse, rat and human origin by WB, IP, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Bag-1 Antibody (A-4). This work is in progress.
Bag-1 Antibody (A-4) is a mouse monoclonal IgG2a antibody that detects BAG1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAG1 is a critical regulator of apoptosis, functioning as a Bcl-2-binding protein that enhances the protective effects of Bcl-2 against cell death. This interaction is particularly important as BAG1 may play a pivotal role in determining cell survival in various physiological and pathological contexts, including cancer. BAG1 can influence the balance between pro-apoptotic and anti-apoptotic signals, thereby affecting cellular responses to stress and contributing to the development of resistance to apoptosis in tumor cells. Understanding the dynamics of BAG1 and its interactions with other proteins in the Bcl-2 family can provide valuable insights into therapeutic strategies aimed at modulating apoptosis in diseases where cell death regulation is disrupted. Anti-BAG1 antibody (A-4) is an essential tool for researchers investigating the mechanisms of apoptosis and the role of Bcl-2 family proteins in cellular health and disease.
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Bag-1 Antibody (A-4) References:
- Bag-1 up-regulation in anti-CD4 mAb-treated allo-activated T cell confers resistance to activation-induced cell death (AICD). | Sawitzki, B., et al. 2002. Transpl Immunol. 9: 83-91. PMID: 12180851
- Distinct BAG-1 isoforms have different anti-apoptotic functions in BAG-1-transfected C33A human cervical carcinoma cell line. | Chen, J., et al. 2002. Oncogene. 21: 7050-9. PMID: 12370827
- BAG-1 proteins protect cardiac myocytes from simulated ischemia/reperfusion-induced apoptosis via an alternate mechanism of cell survival independent of the proteasome. | Townsend, PA., et al. 2004. J Biol Chem. 279: 20723-8. PMID: 14978028
- Nuclear BAG-1 expression inhibits apoptosis in colorectal adenoma-derived epithelial cells. | Barnes, JD., et al. 2005. Apoptosis. 10: 301-11. PMID: 15843891
- Isomorph expression of BAG-1 gene, ER and PR in endometrial cancer. | Porichi, O., et al. 2010. Anticancer Res. 30: 4103-8. PMID: 21036726
- Co-overexpression of Bag-1 and heat shock protein 70 in human epidermal squamous cell carcinoma: Bag-1-mediated resistance to 5-fluorouracil-induced apoptosis. | Wood, J., et al. 2011. Br J Cancer. 104: 1459-71. PMID: 21522149
- BAG-1 expression in human meningioma and correlation with clinical characteristics. | Zhou, K., et al. 2013. Med Oncol. 30: 458. PMID: 23322525
- Association between polymorphisms of BAG-1 and XPD and chemotherapy sensitivity in advanced non-small-cell lung cancer patients treated with vinorelbine combined cisplatin regimen. | Li, P., et al. 2015. Tumour Biol. 36: 9465-73. PMID: 26124006
- Magnetic gold nanoparticle-mediated small interference RNA silencing Bag-1 gene for colon cancer therapy. | Huang, W., et al. 2016. Oncol Rep. 35: 978-84. PMID: 26717967
- The Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA) binds to the G-quadruplex of the BAG-1 5'UTR. | Bolduc, F., et al. 2020. Biochimie. 176: 122-127. PMID: 32629040
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Bag-1 Antibody (A-4) | sc-377419 | 200 µg/ml | $322.00 | |||
Bag-1 (A-4) Neutralizing Peptide | sc-377419 P | 100 µg/0.5 ml | $69.00 |