BAF155 Antibody (F-4): sc-137138

BAF155 Antibody (F-4) is a mouse monoclonal IgG1 antibody that detects BAF155 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). BAF155, also known as SRG3, is a crucial component of the SWI/SNF chromatin remodeling complex, which plays a vital role in the regulation of gene expression by altering nucleosome structure in an ATP-dependent manner. BAF155 is primarily located in the nucleus, where anti-BAF155 antibody (F-4) can detect interactions with other core subunits of the SWI/SNF complex, including Brm, Brg-1, and Ini1, to facilitate chromatin remodeling and promote transcriptional activation. BAF155 is essential for the complex′s overall functionality, enhancing remodeling activity when combined with other subunits, thereby influencing cellular processes such as differentiation and development. Understanding BAF155′s role in chromatin dynamics is important for elucidating mechanisms of gene regulation and potential implications in various diseases, including cancer, where dysregulation of chromatin remodeling can lead to aberrant gene expression. BAF155 monoclonal antibody (F-4) is an invaluable tool for researchers studying these complex biological processes.

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BAF155 Antibody (F-4) References:

1. Regulating SWI/SNF subunit levels via protein-protein interactions and proteasomal degradation: BAF155 and BAF170 limit expression of BAF57.  |  Chen, J. and Archer, TK. 2005. Mol Cell Biol. 25: 9016-27. PMID: 16199878
2. 1H, 15N, and 13C resonance assignments and secondary structure of the SWIRM domain of human BAF155, a chromatin remodeling complex component.  |  Moon, S., et al. 2013. Mol Cells. 36: 333-9. PMID: 23996527
3. CARM1 and BAF155: an example of how chromatin remodeling factors can be relocalized and contribute to cancer.  |  Stefansson, OA. and Esteller, M. 2014. Breast Cancer Res. 16: 307. PMID: 25927994
4. CARM1 Methylates Chromatin Remodeling Factor BAF155 to Enhance Tumor Progression and Metastasis.  |  Wang, L., et al. 2016. Cancer Cell. 30: 179-180. PMID: 27479032
5. Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation.  |  Chen, H., et al. 2019. Emerg Microbes Infect. 8: 1393-1405. PMID: 31533543
6. BAF155 methylation drives metastasis by hijacking super-enhancers and subverting anti-tumor immunity.  |  Kim, EJ., et al. 2021. Nucleic Acids Res. 49: 12211-12233. PMID: 34865122
7. BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination.  |  Zhang, N., et al. 2023. Cell Discov. 9: 46. PMID: 37156792
8. Baf155 regulates skeletal muscle metabolism via HIF-1a signaling.  |  Kang, JS., et al. 2023. PLoS Biol. 21: e3002192. PMID: 37478146
9. Baf155 controls hematopoietic differentiation and regeneration through chromatin priming.  |  Wu, J., et al. 2024. Cell Rep. 43: 114558. PMID: 39088321
10. Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest.  |  Shanahan, F., et al. 1999. Mol Cell Biol. 19: 1460-9. PMID: 9891079

The preferred BAF155 antibody is BAF155 Antibody (DXD7): sc-32763.