BAF155 Antibody (DXD7): sc-32763

BAF155 Antibody (DXD7) is a mouse monoclonal IgG1 kappa light chain antibody that detects BAF155 protein of human origin and, to a lesser extent, from mouse and rat sources by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. BAF155 (DXD7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. BAF155, also known as SRG3, plays a crucial role in the SWI/SNF chromatin remodeling complex, which is essential for regulating gene expression through nucleosome structure remodeling in an ATP-dependent manner. BAF155 functions as part of a core that includes Brm, Brg-1, and Ini1, which together facilitate remodeling activity. BAF155 interaction with these ATPase subunits enhances the remodeling process, influencing transcriptional activation. BAF155 involvement in various cellular processes, including differentiation and development, makes this protein a significant target for studies related to gene regulation and chromatin dynamics. Research on BAF155 and its interactions within the SWI/SNF complex can provide insights into chromatin remodeling mechanisms and their implications in various diseases, including cancer.

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BAF155 Antibody (DXD7) References:

1. Reconstitution of a core chromatin remodeling complex from SWI/SNF subunits.  |  Phelan, ML., et al. 1999. Mol Cell. 3: 247-53. PMID: 10078207
2. Structural Insights into BAF47 and BAF155 Complex Formation.  |  Yan, L., et al. 2017. J Mol Biol. 429: 1650-1660. PMID: 28438634
3. Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation.  |  Chen, H., et al. 2019. Emerg Microbes Infect. 8: 1393-1405. PMID: 31533543
4. BAF155 methylation drives metastasis by hijacking super-enhancers and subverting anti-tumor immunity.  |  Kim, EJ., et al. 2021. Nucleic Acids Res. 49: 12211-12233. PMID: 34865122
5. BAF155 promotes cardiac hypertrophy and fibrosis through inhibition of WWP2-mediated PARP1 ubiquitination.  |  Zhang, N., et al. 2023. Cell Discov. 9: 46. PMID: 37156792
6. Baf155 regulates skeletal muscle metabolism via HIF-1a signaling.  |  Kang, JS., et al. 2023. PLoS Biol. 21: e3002192. PMID: 37478146
7. Baf155 controls hematopoietic differentiation and regeneration through chromatin priming.  |  Wu, J., et al. 2024. Cell Rep. 43: 114558. PMID: 39088321
8. A human homologue of Saccharomyces cerevisiae SNF2/SWI2 and Drosophila brm genes potentiates transcriptional activation by the glucocorticoid receptor.  |  Muchardt, C. and Yaniv, M. 1993. EMBO J. 12: 4279-90. PMID: 8223438
9. BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription.  |  Khavari, PA., et al. 1993. Nature. 366: 170-4. PMID: 8232556
10. ISWI, a member of the SWI2/SNF2 ATPase family, encodes the 140 kDa subunit of the nucleosome remodeling factor.  |  Tsukiyama, T., et al. 1995. Cell. 83: 1021-6. PMID: 8521502
11. Nucleosome disruption by human SWI/SNF is maintained in the absence of continued ATP hydrolysis.  |  Imbalzano, AN., et al. 1996. J Biol Chem. 271: 20726-33. PMID: 8702824
12. Cloning and mapping of SMARCA5 encoding hSNF2H, a novel human homologue of Drosophila ISWI.  |  Aihara, T., et al. 1998. Cytogenet Cell Genet. 81: 191-3. PMID: 9730600

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-BAF155 Antibody (DXD7) has 23 citations in a variety of scientific publications.

Primary antibodies like Anti-BAF155 Antibody (DXD7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

BAF155 Antibody (DXD7) Specifications

Alternate Product Name: SMARCC1

Product Clone Name: DXD7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: BAF155

Epitope Species: human

Product Reactivity/Detection: BAF155

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 23 citations in various scientific publications

Available Conjugates/Forms for BAF155 Antibody (DXD7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent