B7-H4 Antibody (9): sc-66189

B7-H4 Antibody (9) is a rat monoclonal IgG1 antibody that detects B7-H4 protein of mouse origin by flow cytometry (FCM). Anti-B7-H4 antibody (9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. B7-H4 protein, also known as B7-homolog 4 or VTCN1, plays a crucial role in regulating T cell activation and immune responses through immunoinhibitory functions. Primarily expressed on the surface of lymphoid cells, B7-H4 interacts with receptors on T lymphocytes, effectively modulating both cellular and humoral immune responses. This interaction is particularly significant as B7-H4 can suppress tumor-associated immunity, making B7-H4 a key player in the immune evasion of certain malignancies, including ovarian and breast cancer. Notably, B7-H4 overexpression has been linked to these cancers, and ongoing research indicates that, similar to Mucin 16 (CA125), B7-H4 may serve as a valuable biomarker for early detection of ovarian cancer. B7-H4′s ability to influence immune responses highlights its importance in both cancer biology and potential therapeutic strategies, making anti-B7-H4 antibody (9) an essential tool for researchers studying immune regulation and tumor immunology.

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B7-H4 Antibody (9) References:

1. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.  |  Sica, GL., et al. 2003. Immunity. 18: 849-61. PMID: 12818165
2. The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation.  |  Salceda, S., et al. 2005. Exp Cell Res. 306: 128-41. PMID: 15878339
3. The B7 family of immune-regulatory ligands.  |  Collins, M., et al. 2005. Genome Biol. 6: 223. PMID: 15960813
4. B7-h4 is a novel membrane-bound protein and a candidate serum and tissue biomarker for ovarian cancer.  |  Simon, I., et al. 2006. Cancer Res. 66: 1570-5. PMID: 16452214
5. B7-H3 and B7-H4 expression in non-small-cell lung cancer.  |  Sun, Y., et al. 2006. Lung Cancer. 53: 143-51. PMID: 16782226
6. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival.  |  Krambeck, AE., et al. 2006. Proc Natl Acad Sci U S A. 103: 10391-10396. PMID: 16798883
7. The new B7s: playing a pivotal role in tumor immunity.  |  Flies, DB. and Chen, L. 2007. J Immunother. 30: 251-60. PMID: 17414316
8. B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration.  |  Miyatake, T., et al. 2007. Gynecol Oncol. 106: 119-27. PMID: 17509674
9. Suppression of Human T-Cell Responses to β-Cells by Activation of B7-H4 Pathway.  |  Ou, D., et al. 2006. Cell Transplant. 15: 399-410. PMID: 28871868
10. Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers.  |  Song, X., et al. 2020. Cancer Discov. 10: 1872-1893. PMID: 32938586
11. Design and Preclinical Evaluation of a Novel B7-H4-Directed Antibody-Drug Conjugate, AZD8205, Alone and in Combination with the PARP1-Selective Inhibitor AZD5305.  |  Kinneer, K., et al. 2023. Clin Cancer Res. 29: 1086-1101. PMID: 36355054
12. Progestogen-driven B7-H4 contributes to onco-fetal immune tolerance.  |  Yu, J., et al. 2024. Cell. 187: 4713-4732.e19. PMID: 38968937

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-B7-H4 Antibody (9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-B7-H4 Antibody (9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

B7-H4 Antibody (9) Specifications

Alternate Product Name: B7-H4

Product Clone Name: 9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: B7-H4

Epitope Species: mouse

Product Reactivity/Detection: B7-H4

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: FCM

Vialing Information: Each vial contains 200 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for B7-H4 Antibody (9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin