B7-2 Antibody (2Q1692): sc-70396
- B7-2 Antibody (2Q1692) is a rat monoclonal IgG2a, cited in 1 publications, provided at 200 µg/ml
- raised against LPS activated B cells of mouse origin
- recommended for detection of B7-2 of mouse origin by WB, IP, IF and FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also provided azide-free for blocking assays, sc-70396 L, 200 µg/0.1 ml
- See B7-2 (D-6): sc-28347 for B7-2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for B7-2 Antibody (2Q1692). This work is in progress.
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B7-2 Antibody (2Q1692) is a rat monoclonal IgG2a antibody that detects B7-2 in mouse samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). B7-2, also known as CD86, plays a crucial role in the immune response by acting as a costimulatory molecule on antigen-presenting cells, which is essential for T cell activation and proliferation. B7-2 (2Q1692) antibody interacts with the T cell receptors CD28 and CTLA-4, providing necessary signals that enhance T cell responses. B7-2 monoclonal antibody (2Q1692) helps researchers study immune responses through its ability to detect this key protein that modulates immune responses and maintains immune homeostasis. B7-2 is primarily located on the surface of activated dendritic cells and macrophages, where expression increases in response to inflammatory signals, highlighting its role in immune system responses to pathogens. Anti-B7-2 antibody (2Q1692) serves as an invaluable tool for researchers studying T cell activation and immune response signaling pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
B7-2 Antibody (2Q1692) References:
- B7-1 (CD80) and B7-2 (CD86) have complementary roles in mediating allergic pulmonary inflammation and airway hyperresponsiveness. | Mark, DA., et al. 2000. Am J Respir Cell Mol Biol. 22: 265-71. PMID: 10696062
- Ligation of B7-1/B7-2 by human CD4+ T cells triggers indoleamine 2,3-dioxygenase activity in dendritic cells. | Munn, DH., et al. 2004. J Immunol. 172: 4100-10. PMID: 15034022
- Dysregulated B7-1 and B7-2 expression on nonobese diabetic mouse B cells is associated with increased T cell costimulation and the development of insulitis. | Hussain, S. and Delovitch, TL. 2005. J Immunol. 174: 680-7. PMID: 15634886
- Differential contributions of B7-1 and B7-2 to the development of murine experimental allergic conjunctivitis. | Sumi, T., et al. 2007. Immunol Lett. 108: 62-7. PMID: 17109973
- Expression and function of B7-1 and B7-2 in hapten-induced contact sensitivity. | Reiser, H. and Schneeberger, EE. 1996. Eur J Immunol. 26: 880-5. PMID: 8625983
- Prevention and amelioration of collagen-induced arthritis by blockade of the CD28 co-stimulatory pathway: requirement for both B7-1 and B7-2. | Webb, LM., et al. 1996. Eur J Immunol. 26: 2320-8. PMID: 8898940
- Transfection of the gene for B7-1 but not B7-2 can induce immunity to murine malignant mesothelioma. | Leong, CC., et al. 1997. Int J Cancer. 71: 476-82. PMID: 9139887
- Expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86) on human hepatocellular carcinoma. | Tatsumi, T., et al. 1997. Hepatology. 25: 1108-14. PMID: 9141426
- Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice. | Van Parijs, L., et al. 1997. J Immunol. 159: 5336-44. PMID: 9548473
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
B7-2 Antibody (2Q1692) | sc-70396 | 200 µg/ml | $322.00 | |||
B7-2 Antibody (2Q1692) FITC | sc-70396 FITC | 200 µg/ml | $336.00 | |||
B7-2 Antibody (2Q1692) L | sc-70396 L | 200 µg/0.1 ml | $322.00 | |||
B7-2 Antibody (2Q1692) PE | sc-70396 PE | 200 µg/ml | $349.00 |