β3Gn-TL1 Antibody (A-9): sc-514293

β3Gn-TL1 Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects β3Gn-TL1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). β3Gn-TL1 (A-9) antibody is available in non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. β3Gn-TL1, also known as UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like protein 1, consists of 361 amino acids and belongs to the glycosyltransferase 2 family, playing a crucial role in glycosyl group transfer. This transferase activity supports cell signaling, protein folding, and cellular structure maintenance. β3Gn-TL1 shows highest expression in adult pancreas, with moderate levels in kidney, spleen, thymus, prostate, testis, and ovary, and lower expression in small intestine, colon, peripheral blood leukocytes, and liver. β3Gn-TL1 gene conservation spans multiple species, including chimpanzees, mice, rats, chickens, zebrafish, and Caenorhabditis elegans, with location on human chromosome 17q25.3, which makes up over 2.5% of the human genome and contains more than 1,200 genes. Chromosome 17′s association with genetic disorders like Alexander disease, Birt-Hogg-Dube syndrome, and Canavan disease underscores the importance of understanding β3Gn-TL1′s functions and interactions in health and disease.

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β3Gn-TL1 Antibody (A-9) References:

1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.  |  Strausberg, RL., et al. 2002. Proc Natl Acad Sci U S A. 99: 16899-903. PMID: 12477932
2. Complete sequencing and characterization of 21,243 full-length human cDNAs.  |  Ota, T., et al. 2004. Nat Genet. 36: 40-5. PMID: 14702039
3. Characterization of a cDNA encoding a protein with limited similarity to beta1, 3-N-acetylglucosaminyltransferase.  |  Zheng, H., et al. 2004. Mol Biol Rep. 31: 171-5. PMID: 15560372
4. Quantification of N-acetylaspartic acid in urine by LC-MS/MS for the diagnosis of Canavan disease.  |  Al-Dirbashi, OY., et al. 2007. J Inherit Metab Dis. 30: 612. PMID: 17632691
5. Novel deletion mutation in GFAP gene in an infantile form of Alexander disease.  |  Murakami, N., et al. 2008. Pediatr Neurol. 38: 50-2. PMID: 18054694
6. Exploring the human genome with functional maps.  |  Huttenhower, C., et al. 2009. Genome Res. 19: 1093-106. PMID: 19246570
7. Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy.  |  Davé, UP., et al. 2009. PLoS Genet. 5: e1000491. PMID: 19461887
8. Abnormal N-acetylglucosaminyltransferase expression in prefrontal cortex in schizophrenia.  |  Kippe, JM., et al. 2015. Schizophr Res. 166: 219-24. PMID: 26104473
9. B3GNT3: A prognostic biomarker associated with immune cell infiltration in pancreatic adenocarcinoma.  |  Kong, K., et al. 2021. Oncol Lett. 21: 159. PMID: 33552277
10. Constructing a molecular subtype model of colon cancer using machine learning.  |  Zhou, B., et al. 2022. Front Pharmacol. 13: 1008207. PMID: 36188575
11. G-quadruplex-enhanced circular single-stranded DNA (G4-CSSD) adsorption of miRNA to inhibit colon cancer progression.  |  Wu, H., et al. 2023. Cancer Med. 12: 9774-9787. PMID: 36855796
12. A beta-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to beta-1,3-galactosyltransferases.  |  Zhou, D., et al. 1999. Proc Natl Acad Sci U S A. 96: 406-11. PMID: 9892646

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-β3Gn-TL1 Antibody (A-9) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-β3Gn-TL1 Antibody (A-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

β3Gn-TL1 Antibody (A-9) Specifications

Alternate Product Name: β3Gn-TL1

Product Clone Name: A-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 20-215

Epitope Target: β3Gn-TL1

Epitope Species: human

Product Reactivity/Detection: β3Gn-TL1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for β3Gn-TL1 Antibody (A-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin