ATP7B Antibody (A-11): sc-373964

ATP7B Antibody (A-11) is a mouse monoclonal IgG1 kappa light chain antibody that detects ATP7B of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ATP7B (A-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ATP7B plays a crucial role in copper homeostasis by facilitating the excretion of excess copper from cells, which is vital for preventing copper toxicity and maintaining cellular function. Located primarily in the liver, ATP7B is essential for regulating copper levels in the body, as ATP7B helps to transport copper into bile for excretion. Dysfunction of ATP7B due to genetic mutations leads to Wilson disease, a serious condition characterized by copper accumulation in tissues, resulting in neurological and hepatic damage. ATP7B′s ability to manage copper levels underscores ATP7B′s importance in both health and disease, making anti-ATP7B antibody (A-11) a valuable tool for researchers studying copper metabolism and related disorders.

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ATP7B Antibody (A-11) References:

1. The distinct functional properties of the nucleotide-binding domain of ATP7B, the human copper-transporting ATPase: analysis of the Wilson disease mutations E1064A, H1069Q, R1151H, and C1104F.  |  Morgan, CT., et al. 2004. J Biol Chem. 279: 36363-71. PMID: 15205462
2. Modulation of the cellular pharmacology of cisplatin and its analogs by the copper exporters ATP7A and ATP7B.  |  Samimi, G., et al. 2004. Mol Pharmacol. 66: 25-32. PMID: 15213293
3. Signals regulating trafficking of Menkes (MNK; ATP7A) copper-translocating P-type ATPase in polarized MDCK cells.  |  Greenough, M., et al. 2004. Am J Physiol Cell Physiol. 287: C1463-71. PMID: 15269005
4. Copper-dependent protein-protein interactions studied by yeast two-hybrid analysis.  |  van Dongen, EM., et al. 2004. Biochem Biophys Res Commun. 323: 789-95. PMID: 15381069
5. Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells.  |  Song, IS., et al. 2004. Mol Cancer Ther. 3: 1543-9. PMID: 15634647
6. The copper-transporting ATPases, menkes and wilson disease proteins, have distinct roles in adult and developing cerebellum.  |  Barnes, N., et al. 2005. J Biol Chem. 280: 9640-5. PMID: 15634671
7. [Wilson disease].  |  Huster, D., et al. 2005. Internist (Berl). 46: 731-2, 734-6, 738-40. PMID: 15915361
8. Diverse functional properties of Wilson disease ATP7B variants.  |  Huster, D., et al. 2012. Gastroenterology. 142: 947-956.e5. PMID: 22240481
9. A structural model of the copper ATPase ATP7B to facilitate analysis of Wilson disease-causing mutations and studies of the transport mechanism.  |  Schushan, M., et al. 2012. Metallomics. 4: 669-78. PMID: 22692182
10. Spectrum and Classification of ATP7B Variants in a Large Cohort of Chinese Patients with Wilson's Disease Guides Genetic Diagnosis.  |  Dong, Y., et al. 2016. Theranostics. 6: 638-49. PMID: 27022412
11. Direct Measurement of ATP7B Peptides Is Highly Effective in the Diagnosis of Wilson Disease.  |  Collins, CJ., et al. 2021. Gastroenterology. 160: 2367-2382.e1. PMID: 33640437

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ATP7B Antibody (A-11) has 10 citations in a variety of scientific publications.

Primary antibodies like Anti-ATP7B Antibody (A-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ATP7B Antibody (A-11) Specifications

Alternate Product Name: ATP7B

Product Clone Name: A-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1372-1465

Epitope Target: ATP7B

Epitope Species: human

Product Reactivity/Detection: ATP7B isoforms a and b

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 10 citations in various scientific publications

Available Conjugates/Forms for ATP7B Antibody (A-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin