Atm Antibody (ATM 11G12): sc-53173

Atm Antibody (ATM 11G12) is a mouse monoclonal IgG1 kappa light chain antibody, specifically designed to detect the Ataxia Telangiectasia Mutated (ATM) protein. ATM monoclonal antibody (ATM 11G12) targets the epitope spanning amino acids 992-1144 of the human ATM protein, ensuring reliable performance in western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. The ATM protein is a crucial member of the phosphatidylinositol 3-kinase-related kinase (PIKK) family, distinguished by its complex structure that includes multiple HEAT repeats and a central kinase domain. This intricate architecture is essential for ATM′s role in orchestrating the cellular response to DNA double-strand breaks, facilitating DNA repair, cell cycle control, and apoptosis to maintain genomic stability. Understanding the structure of ATM is vital as ATM′s ability to interact with various substrates and regulatory proteins modulates critical signaling pathways involved in cellular homeostasis and stress responses. Mutations in the ATM gene are responsible for the autosomal recessive disorder ataxia telangiectasia, which is characterized by neurodegeneration, immune deficiencies, and an increased predisposition to cancer, highlighting ATM′s significance in normal cellular function and disease. Anti-ATM antibody (ATM 11G12) is an essential tool for researchers investigating the molecular mechanisms of ATM, enabling detailed studies of expression, localization, and interaction with other proteins.

The preferred p-Atm antibody is p-Atm Antibody (10H11.E12): sc-47739.