Atlastin Antibody (E-9): sc-376619

Atlastin Antibody (E-9) is a mouse monoclonal IgG1 antibody that detects Atlastin in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Atlastin is a crucial Golgi-localized integral membrane protein that functions as a GTPase, playing a significant role in maintaining axonal integrity. Atlastin′s importance is underscored by involvement in hereditary spastic paraplegia (HSP), a neurodegenerative disorder characterized by the degeneration of long corticospinal neurons, leading to spasticity and weakness in the lower extremities. Atlastin interacts with Spastin, a microtubule-severing AAA ATPase, which is essential for membrane dynamics and cellular transport. This interaction is believed to be a key factor in the biochemical pathways that contribute to the development of HSP. Notably, mutations in the Atlastin gene (SPG3A) are responsible for approximately 10% of all autosomal dominant cases of HSP, highlighting the critical role of Atlastin in neuronal health and disease. Anti-Atlastin antibody (E-9) is an invaluable tool for researchers studying the molecular mechanisms underlying neurodegenerative disorders and the cellular functions of GTPases.

The preferred Atlastin antibody is Atlastin Antibody (B-12): sc-374175.