ATF-7IP Antibody (E-6): sc-514220

ATF-7IP Antibody (E-6) is a mouse monoclonal IgG1 antibody that detects ATF-7IP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ATF-7IP, also known as Activating Transcription Factor 7-Interacting Protein, is a 1,270 amino acid protein encoded by the human gene ATF7IP, which plays a significant role in gene expression regulation. ATF-7IP is primarily located in the nucleus, where ATF-7IP functions as a key player in recruiting transcription factors to the general transcription apparatus, thereby influencing transcription regulation and chromatin structure. Nuclear localization of ATF-7IP enables direct interaction with other nuclear proteins and complexes, facilitating transcriptional activity modulation in response to various cellular signals. Additionally, ATF-7IP mediates MBD1-dependent transcriptional repression by recruiting histone methyltransferase SETDB1, essential for histone H3 trimethylation at ′Lys-9′. This post-translational modification establishes repressive chromatin states, connecting DNA methylation to histone modification and playing a crucial role in gene silencing and chromatin remodeling. ATF-7IP (E-6) antibody serves as an invaluable tool for researchers studying gene regulation and chromatin dynamics in human cells.

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ATF-7IP Antibody (E-6) References:

1. Identification of proteins interacting with human SP110 during the process of viral infections.  |  Cai, L., et al. 2011. Med Chem. 7: 121-6. PMID: 21222611
2. Sensitisation of c-MYC-induced B-lymphoma cells to apoptosis by ATF2.  |  Walczynski, J., et al. 2014. Oncogene. 33: 1027-36. PMID: 23416976
3. The Transcription Factor ATF7 Controls Adipocyte Differentiation and Thermogenic Gene Programming.  |  Liu, Y., et al. 2019. iScience. 13: 98-112. PMID: 30826729
4. Hepatitis B virus-regulated growth of liver cancer cells occurs through the microRNA-340-5p-activating transcription factor 7-heat shock protein A member 1B axis.  |  Song, F., et al. 2019. Cancer Sci. 110: 1633-1643. PMID: 30891870
5. Stress-induced and ATF7-dependent epigenetic change influences cellular senescence.  |  Maekawa, T., et al. 2019. Genes Cells. 24: 627-635. PMID: 31294895
6. miR-340-5p inhibits sheep adipocyte differentiation by targeting ATF7.  |  Liu, H., et al. 2020. Anim Sci J. 91: e13462. PMID: 33190272
7. Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity.  |  Hu, H., et al. 2021. Cancer Immunol Res. 9: 1298-1315. PMID: 34462284
8. lncRNA prostate cancer-associated transcript 18 upregulates activating transcription factor 7 to prevent metastasis of triple-negative breast cancer via sponging miR-103a-3p.  |  Zhang, J., et al. 2021. Bioengineered. 12: 12070-12086. PMID: 34787047
9. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses.  |  Sin, JH., et al. 2022. J Immunol. 208: 1155-1169. PMID: 35110421
10. ATF7-dependent epigenetic changes induced by high temperature during early porcine embryonic development.  |  Sun, MH., et al. 2023. Cell Prolif. 56: e13352. PMID: 36254813

The preferred ATF-7IP antibody is ATF-7IP Antibody (C-1): sc-166753.