ATF-7IP Antibody (C-1): sc-166753

ATF-7IP Antibody (C-1) is a mouse monoclonal IgM antibody that detects ATF-7IP of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ATF-7IP (C-1) antibody is available as the non-conjugated form. ATF-7IP, also known as Activating Transcription Factor 7-Interacting Protein 1, is a 1,270 amino acid protein encoded by the human gene ATF7IP. ATF-7IP plays a crucial role in transcriptional regulation, acting as both an activator and a repressor depending on the cellular context. ATF-7IP is involved in recruiting transcription factors to the general transcription apparatus, which is essential for modulating transcription regulation and chromatin formation. ATF-7IP interacts with MBD1 and SETDB1, mediating MBD1-dependent transcriptional repression by recruiting complexes that enhance histone methyltransferase activity. This interaction is vital for converting dimethylated to trimethylated histone H3 at ′Lys-9′, linking DNA methylation to histone modification and influencing gene expression. ATF-7IP′s role in facilitating these processes underscores its importance in epigenetic regulation and cellular function, making ATF-7IP a valuable target for research in gene expression and chromatin dynamics.

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ATF-7IP Antibody (C-1) References:

1. A murine ATFa-associated factor with transcriptional repressing activity.  |  De Graeve, F., et al. 2000. Oncogene. 19: 1807-19. PMID: 10777215
2. mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.  |  Wang, H., et al. 2003. Mol Cell. 12: 475-87. PMID: 14536086
3. Transcriptional repression and heterochromatin formation by MBD1 and MCAF/AM family proteins.  |  Ichimura, T., et al. 2005. J Biol Chem. 280: 13928-35. PMID: 15691849
4. Activation of Sp1-mediated transcription by Rta of Epstein-Barr virus via an interaction with MCAF1.  |  Chang, LK., et al. 2005. Nucleic Acids Res. 33: 6528-39. PMID: 16314315
5. Involvement of SUMO modification in MBD1- and MCAF1-mediated heterochromatin formation.  |  Uchimura, Y., et al. 2006. J Biol Chem. 281: 23180-90. PMID: 16757475
6. Temporal expression of factors involved in chromatin remodeling and in gene regulation during early bovine in vitro embryo development.  |  McGraw, S., et al. 2007. Reproduction. 133: 597-608. PMID: 17379654
7. [Nuclear atypia and epigenetic change].  |  Ichimura, T. and Ito, T. 2006. Tanpakushitsu Kakusan Koso. 51: 2049-51. PMID: 17471907
8. Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease.  |  Jansen, MP., et al. 2015. Mol Oncol. 9: 1218-33. PMID: 25771305
9. Correction to: Exploring the Genetic Association of the ABAT Gene with Alzheimer's Disease.  |  Zheng, Q., et al. 2021. Mol Neurobiol. 58: 1904. PMID: 33483904
10. Regulation of Gamma-Aminobutyric Acid Transaminase Expression and Its Clinical Significance in Hepatocellular Carcinoma.  |  Gao, X., et al. 2022. Front Oncol. 12: 879810. PMID: 35847853
11. [Corrigendum] Role of 4‑aminobutyrate aminotransferase (ABAT) and the lncRNA co‑expression network in the development of myelodysplastic syndrome.  |  Chen, Y., et al. 2023. Oncol Rep. 49: PMID: 36416343
12. Alignment-Based Adversarial Training (ABAT) for Improving the Robustness and Accuracy of EEG-Based BCIs.  |  Chen, X., et al. 2024. IEEE Trans Neural Syst Rehabil Eng. 32: 1703-1714. PMID: 38648154

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ATF-7IP Antibody (C-1) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ATF-7IP Antibody (C-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ATF-7IP Antibody (C-1) Specifications

Alternate Product Name: ATF-7IP

Product Clone Name: C-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 1058-1161

Epitope Target: ATF-7IP

Epitope Species: mouse

Product Reactivity/Detection: ATF-7IP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ATF-7IP Antibody (C-1): N/A