ATF-7IP Antibody (B-7): sc-166767

ATF-7IP Antibody (B-7) is a mouse monoclonal IgG2a antibody that detects ATF-7IP in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ATF-7IP, also known as Activating Transcription Factor 7-Interacting Protein, is a 1,270 amino acid protein encoded by the human gene ATF7IP, playing a crucial role in gene expression regulation. ATF-7IP is primarily located in the nucleus, functioning as a key player in recruiting transcription factors to the general transcription machinery, thereby influencing transcription regulation and chromatin structure. Nuclear localization of ATF-7IP enables direct interaction with other nuclear proteins and complexes, facilitating transcriptional activity modulation in response to various cellular signals. ATF-7IP mediates MBD1-dependent transcriptional repression by recruiting the SETDB1 complex, essential for histone methylation processes. ATF-7IP stimulates SETDB1 histone methyltransferase activity and facilitates dimethylated to trimethylated H3 "Lys 9" conversion, highlighting significance in epigenetic regulation and linking DNA methylation to histone modifications. Through these roles in transcriptional regulation and chromatin dynamics, ATF-7IP serves as a significant protein for understanding gene expression mechanisms and biological process implications.

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ATF-7IP Antibody (B-7) References:

1. MCAF1/AM is involved in Sp1-mediated maintenance of cancer-associated telomerase activity.  |  Liu, L., et al. 2009. J Biol Chem. 284: 5165-74. PMID: 19106100
2. Identification of proteins interacting with human SP110 during the process of viral infections.  |  Cai, L., et al. 2011. Med Chem. 7: 121-6. PMID: 21222611
3. Hypersomnolence-hyperkinetic movement disorder in a child with compound heterozygous mutation in 4-aminobutyrate aminotransferase (ABAT) gene.  |  Nagappa, M., et al. 2017. Brain Dev. 39: 161-165. PMID: 27596361
4. The epigenetic regulator ATF7ip inhibits Il2 expression, regulating Th17 responses.  |  Sin, JH., et al. 2019. J Exp Med. 216: 2024-2037. PMID: 31217192
5. Inhibition of 4-aminobutyrate aminotransferase protects against injury-induced osteoarthritis in mice.  |  Shen, J., et al. 2019. JCI Insight. 4: PMID: 31534049
6. Targeting the Atf7ip-Setdb1 Complex Augments Antitumor Immunity by Boosting Tumor Immunogenicity.  |  Hu, H., et al. 2021. Cancer Immunol Res. 9: 1298-1315. PMID: 34462284
7. Human epidermal growth factor receptor 2 inhibits activating transcription factor 7 to promote breast cancer cell migration by activating histone lysine demethylase 1.  |  Lin, J., et al. 2021. J Cancer Res Ther. 17: 1192-1201. PMID: 34850767
8. ATF7ip Targets Transposable Elements for H3K9me3 Deposition to Modify CD8+ T Cell Effector and Memory Responses.  |  Sin, JH., et al. 2022. J Immunol. 208: 1155-1169. PMID: 35110421
9. Epigenetic dysregulation of articular cartilage during progression of hip femoroacetabular impingement disease.  |  Kamenaga, T., et al. 2023. J Orthop Res. 41: 1678-1686. PMID: 36606425
10. HNEAP Regulates Necroptosis of Cardiomyocytes by Suppressing the m5 C Methylation of Atf7 mRNA.  |  Wang, K., et al. 2023. Adv Sci (Weinh). 10: e2304329. PMID: 37870216

The preferred ATF-7IP antibody is ATF-7IP Antibody (C-1): sc-166753.