ATF3 Antibody (44C3a): sc-81189

ATF-3 Antibody (44C3a) is a mouse monoclonal IgG1 kappa light chain antibody that detects ATF-3 of human and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-ATF-3 antibody (44C3a) is available as the non-conjugated format. ATF-3 plays a crucial role in cellular stress responses and regulates various genes associated with inflammation, apoptosis, and cell survival. ATF-3 expression increases in response to stress signals, such as oxidative stress or cytokine stimulation, making ATF-3 a key player in adaptive cellular responses to adverse conditions. ATF-3 modulates gene expression to maintain cellular homeostasis and prevent pathological conditions, such as chronic inflammation or cancer. ATF-3 can form heterodimers with other transcription factors, enhancing regulatory capabilities and allowing for a more nuanced response to cellular signals. This multifaceted role underscores ATF-3 significance in both normal physiology and disease states, making ATF-3 a valuable target for research in understanding stress-related cellular mechanisms.

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ATF3 Antibody (44C3a) References:

1. Molecular cloning of human CREB-2: an ATF/CREB transcription factor that can negatively regulate transcription from the cAMP response element.  |  Karpinski, BA., et al. 1992. Proc Natl Acad Sci U S A. 89: 4820-4. PMID: 1534408
2. The transcription factor ATF-3 promotes neurite outgrowth.  |  Seijffers, R., et al. 2006. Mol Cell Neurosci. 32: 143-54. PMID: 16713293
3. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity.  |  Hai, T. and Curran, T. 1991. Proc Natl Acad Sci U S A. 88: 3720-4. PMID: 1827203
4. Neuronal injury marker ATF-3 is induced in primary afferent neurons of monoarthritic rats.  |  Nascimento, D., et al. 2011. Neurosignals. 19: 210-21. PMID: 21912089
5. A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain.  |  Kara, CJ., et al. 1990. Mol Cell Biol. 10: 1347-57. PMID: 2320002
6. Upregulation of ATF-3 is correlated with prognosis and proliferation of laryngeal cancer by regulating Cyclin D1 expression.  |  Feng, J., et al. 2013. Int J Clin Exp Pathol. 6: 2064-70. PMID: 24133584
7. Metformin suppresses lipopolysaccharide (LPS)-induced inflammatory response in murine macrophages via activating transcription factor-3 (ATF-3) induction.  |  Kim, J., et al. 2014. J Biol Chem. 289: 23246-23255. PMID: 24973221
8. Transcription factor ATF cDNA clones: an extensive family of leucine zipper proteins able to selectively form DNA-binding heterodimers.  |  Hai, TW., et al. 1989. Genes Dev. 3: 2083-90. PMID: 2516827
9. Interaction of a common cellular transcription factor, ATF, with regulatory elements in both E1a- and cyclic AMP-inducible promoters.  |  Lin, YS. and Green, MR. 1988. Proc Natl Acad Sci U S A. 85: 3396-400. PMID: 2835770
10. Identification of a cyclic-AMP-responsive element within the rat somatostatin gene.  |  Montminy, MR., et al. 1986. Proc Natl Acad Sci U S A. 83: 6682-6. PMID: 2875459
11. Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA.  |  Hoeffler, JP., et al. 1988. Science. 242: 1430-3. PMID: 2974179
12. ATF-3 expression inhibits melanoma growth by downregulating ERK and AKT pathways.  |  Zu, T., et al. 2021. Lab Invest. 101: 636-647. PMID: 33299127

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ATF3 Antibody (44C3a) has 28 citations in a variety of scientific publications.

Primary antibodies like Anti-ATF3 Antibody (44C3a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ATF3 Antibody (44C3a) Specifications

Alternate Product Name: ATF3

Product Clone Name: 44C3a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: ATF-3

Epitope Species: human

Product Reactivity/Detection: ATF-3

Species Reactivity/Detection: human, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 28 citations in various scientific publications

Available Conjugates/Forms for ATF3 Antibody (44C3a): N/A

The preferred ATF3 antibody is ATF3 Antibody (A-8): sc-518032.