ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (A-5): sc-393849

ASGPR1 Antibody (A-5) is a mouse monoclonal IgG1 kappa light chain antibody that detects ASGPR1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ASGPR1 (A-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The Asialoglycoprotein Receptor (ASGPR), also known as hepatic lectin, is a type II integral membrane protein predominantly expressed in hepatic cells, where ASGPR plays a crucial role in glycoprotein endocytosis. ASGPR1 is composed of two homologous subunits, ASGPR1 and ASGPR2, which form multimeric complexes and contain four functional domains: a cytosolic domain, a transmembrane domain, a stalk domain, and a carbohydrate recognition domain (CRD). The CRD enables ASGPR to selectively bind glycoproteins that have terminal galactose and N-acetylgalactosamine residues in the presence of calcium, facilitating ASGPR-glycoprotein complex internalization into cells. Once internalized, the receptor and ligand dissociate, allowing ASGPR to recycle back to the cell membrane. ASGPR can also interact with the hepatitis B virus (HBV), mediating HBV infection of liver cells, which highlights ASGPR′s potential as a therapeutic target in treating HBV-related diseases.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (A-5) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (A-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (A-5) Specifications

Alternate Product Name: asialoglycoprotein (ASGPR) receptor 1

Product Clone Name: A-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2-27

Epitope Target: ASGPR1

Epitope Species: human

Product Reactivity/Detection: ASGPR1

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (A-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 antibody is ASGPR1/Asialoglycoprotein Receptor 1/ASGR1 Antibody (8D7): sc-52623.