ASCT1 Antibody (C-8): sc-393157
- ASCT1 Antibody (C-8) is a mouse monoclonal IgG1 κ ASCT1 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 112-171 mapping within an internal region of ASCT1 of human origin
- ASCT1 Antibody (C-8) is recommended for detection of ASCT1 of human origin by WB, IP, IF and ELISA
- Anti-ASCT1 Antibody (C-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ASCT1 Antibody (C-8) for WB applications. These reagents are now offered in bundles with ASCT1 Antibody (C-8) (see ordering information below).
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ASCT1 Antibody (C-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects ASCT1 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ASCT1 antibody (C-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ASCT1, a member of the alanine/serine/cysteine/threonine transporter family, plays a crucial role in the transport of neutral amino acids across cell membranes, which is vital for maintaining cellular homeostasis and supporting metabolic processes. ASCT1 is predominantly located in the plasma membrane of cells, where ASCT1 facilitates the uptake of essential amino acids like threonine, alanine, serine, and cysteine, thereby influencing protein synthesis and energy metabolism. ASCT1 is expressed in various tissues, with the highest levels found in muscle, brain, and pancreas, highlighting ASCT1′s importance in both neural and metabolic functions. The sodium-dependent nature of ASCT1 and ASCT1′s interaction with other transporters, such as ASCT2, further underscores ASCT1′s significance in amino acid transport and cellular nutrient uptake, making anti-ASCT1 antibody (C-8) an essential tool for researchers studying amino acid transport mechanisms and related physiological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ASCT1 Antibody (C-8) References:
- The RD114/simian type D retrovirus receptor is a neutral amino acid transporter. | Rasko, JE., et al. 1999. Proc Natl Acad Sci U S A. 96: 2129-34. PMID: 10051606
- A sodium-dependent neutral-amino-acid transporter mediates infections of feline and baboon endogenous retroviruses and simian type D retroviruses. | Tailor, CS., et al. 1999. J Virol. 73: 4470-4. PMID: 10196349
- Truncated forms of the dual function human ASCT2 neutral amino acid transporter/retroviral receptor are translationally initiated at multiple alternative CUG and GUG codons. | Tailor, CS., et al. 2001. J Biol Chem. 276: 27221-30. PMID: 11350958
- The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects. | Kanai, Y. and Hediger, MA. 2004. Pflugers Arch. 447: 469-79. PMID: 14530974
- Functional identification of ASCT1 neutral amino acid transporter as the predominant system for the uptake of L-serine in rat neurons in primary culture. | Yamamoto, T., et al. 2004. Neurosci Res. 49: 101-11. PMID: 15099708
- Distribution of neutral amino acid transporter ASCT 1 in the non-neuronal tissues of mice. | Hashimoto, Y., et al. 2004. Jpn J Vet Res. 52: 113-24. PMID: 15631009
- Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. | Arriza, JL., et al. 1993. J Biol Chem. 268: 15329-32. PMID: 8101838
- Cloning of the sodium-dependent, broad-scope, neutral amino acid transporter Bo from a human placental choriocarcinoma cell line. | Kekuda, R., et al. 1996. J Biol Chem. 271: 18657-61. PMID: 8702519
- Human neutral amino acid transporter ASCT1: structure of the gene (SLC1A4) and localization to chromosome 2p13-p15. | Hofmann, K., et al. 1994. Genomics. 24: 20-6. PMID: 7896285
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ASCT1 Antibody (C-8) | sc-393157 | 200 µg/ml | $316.00 | |||
ASCT1 Antibody (C-8): m-IgG Fc BP-HRP Bundle | sc-530374 | 200 µg Ab; 10 µg BP | $354.00 | |||
ASCT1 Antibody (C-8): m-IgGκ BP-HRP Bundle | sc-523828 | 200 µg Ab, 40 µg BP | $354.00 | |||
ASCT1 Antibody (C-8): m-IgG1 BP-HRP Bundle | sc-544022 | 200 µg Ab; 20 µg BP | $354.00 | |||
ASCT1 Antibody (C-8) AC | sc-393157 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ASCT1 Antibody (C-8) HRP | sc-393157 HRP | 200 µg/ml | $316.00 | |||
ASCT1 Antibody (C-8) FITC | sc-393157 FITC | 200 µg/ml | $330.00 | |||
ASCT1 Antibody (C-8) PE | sc-393157 PE | 200 µg/ml | $343.00 | |||
ASCT1 Antibody (C-8) Alexa Fluor® 488 | sc-393157 AF488 | 200 µg/ml | $357.00 | |||
ASCT1 Antibody (C-8) Alexa Fluor® 546 | sc-393157 AF546 | 200 µg/ml | $357.00 | |||
ASCT1 Antibody (C-8) Alexa Fluor® 594 | sc-393157 AF594 | 200 µg/ml | $357.00 | |||
ASCT1 Antibody (C-8) Alexa Fluor® 647 | sc-393157 AF647 | 200 µg/ml | $357.00 | |||
ASCT1 Antibody (C-8) Alexa Fluor® 680 | sc-393157 AF680 | 200 µg/ml | $357.00 | |||
ASCT1 Antibody (C-8) Alexa Fluor® 790 | sc-393157 AF790 | 200 µg/ml | $357.00 |