ASCL1 Antibody (G-7): sc-390794
- ASCL1 Antibody (G-7) is a mouse monoclonal IgG2a κ ASCL1 antibody, cited in 9 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 187-205 of ASCL1 of human origin
- ASCL1 Antibody (G-7) is recommended for detection of ASCL1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including canine
- TransCruz reagent for ChIP application (sc-390794 X, 200 µg/0.1 ml)
- Anti-ASCL1 Antibody (G-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ASCL1 Antibody (G-7) for WB applications. These reagents are now offered in bundles with ASCL1 Antibody (G-7) (see ordering information below).
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ASCL1 Antibody (G-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects ASCL1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ASCL1 (G-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ASCL1 protein, also known as Achaete-Scute Homolog 1, is a basic helix-loop-helix transcription factor that plays a crucial role in early nervous system development, particularly in autonomic neuron formation and survival. ASCL1 expression is predominantly observed in fetal brain, where ASCL1 is essential for proper neuronal circuit development. ASCL1 interacts with MEF-2A protein, which may influence expression of genes vital for establishing distinct neuronal pathways within central nervous system. ASCL1 shows high expression levels in neuroendocrine tumors, such as medullary thyroid cancer and small cell lung cancer, making ASCL1 a potential biomarker for cancers exhibiting neuroendocrine characteristics. ASCL1 gene is located on human chromosome 12 and contains a trinucleotide repeat region, positioning ASCL1 as a candidate for inherited diseases.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ASCL1 Antibody (G-7) References:
- The homeobox gene Phox2b is essential for the development of autonomic neural crest derivatives. | Pattyn, A., et al. 1999. Nature. 399: 366-70. PMID: 10360575
- HASH-1 and E2-2 are expressed in human neuroblastoma cells and form a functional complex. | Persson, P., et al. 2000. Biochem Biophys Res Commun. 274: 22-31. PMID: 10903890
- Mammalian achaete-scute homolog 1 is transiently expressed by spatially restricted subsets of early neuroepithelial and neural crest cells. | Lo, LC., et al. 1991. Genes Dev. 5: 1524-37. PMID: 1909283
- Induction of a serotonergic and neuronal phenotype in thyroid C-cells. | Clark, MS., et al. 1995. J Neurosci. 15: 6167-78. PMID: 7666199
- Identification of a human achaete-scute homolog highly expressed in neuroendocrine tumors. | Ball, DW., et al. 1993. Proc Natl Acad Sci U S A. 90: 5648-52. PMID: 8390674
- Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A. | Mao, Z. and Nadal-Ginard, B. 1996. J Biol Chem. 271: 14371-5. PMID: 8662987
- Differentiation of medullary thyroid cancer by C-Raf-1 silences expression of the neural transcription factor human achaete-scute homolog-1. | Chen, H., et al. 1996. Surgery. 120: 168-72; discussion 173. PMID: 8751579
- Conservation of the Drosophila lateral inhibition pathway in human lung cancer: a hairy-related protein (HES-1) directly represses achaete-scute homolog-1 expression. | Chen, H., et al. 1997. Proc Natl Acad Sci U S A. 94: 5355-60. PMID: 9144241
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ASCL1 Antibody (G-7) | sc-390794 | 200 µg/ml | $322.00 | |||
ASCL1 Antibody (G-7): m-IgG Fc BP-HRP Bundle | sc-530266 | 200 µg Ab; 10 µg BP | $361.00 | |||
ASCL1 Antibody (G-7): m-IgGκ BP-HRP Bundle | sc-523687 | 200 µg Ab, 40 µg BP | $361.00 | |||
ASCL1 Antibody (G-7): m-IgG2a BP-HRP Bundle | sc-547469 | 200 µg Ab; 10 µg BP | $361.00 | |||
ASCL1 Antibody (G-7) X | sc-390794 X | 200 µg/0.1 ml | $322.00 | |||
ASCL1 Antibody (G-7) AC | sc-390794 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ASCL1 Antibody (G-7) HRP | sc-390794 HRP | 200 µg/ml | $322.00 | |||
ASCL1 Antibody (G-7) FITC | sc-390794 FITC | 200 µg/ml | $336.00 | |||
ASCL1 Antibody (G-7) PE | sc-390794 PE | 200 µg/ml | $349.00 | |||
ASCL1 Antibody (G-7) Alexa Fluor® 488 | sc-390794 AF488 | 200 µg/ml | $364.00 | |||
ASCL1 Antibody (G-7) Alexa Fluor® 546 | sc-390794 AF546 | 200 µg/ml | $364.00 | |||
ASCL1 Antibody (G-7) Alexa Fluor® 594 | sc-390794 AF594 | 200 µg/ml | $364.00 | |||
ASCL1 Antibody (G-7) Alexa Fluor® 647 | sc-390794 AF647 | 200 µg/ml | $364.00 | |||
ASCL1 Antibody (G-7) Alexa Fluor® 680 | sc-390794 AF680 | 200 µg/ml | $364.00 | |||
ASCL1 Antibody (G-7) Alexa Fluor® 790 | sc-390794 AF790 | 200 µg/ml | $364.00 | |||
ASCL1 (G-7) Neutralizing Peptide | sc-390794 P | 100 µg/0.5 ml | $69.00 |