ASC-1 Antibody (D-4): sc-365611

ASC-1 Antibody (D-4) is a mouse monoclonal IgG1 antibody that detects Activating Signal Co-integrator-1 (ASC-1) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ASC-1, originally identified as TRIP4, serves as a crucial transcriptional co-activator of nuclear receptors, playing a significant role in gene expression regulation by interacting with RNA polymerase II complex components and binding to essential basal transcription factors like TBP and TFIIA. ASC-1 (D-4) antibody recognizes a protein structure that includes a zinc finger motif facilitating interaction with transcription integrators, such as SRC-1 and CBP/p300, which are vital for ligand-dependent transactivation. ASC-1 localizes predominantly in the nucleus under normal conditions but can translocate to the cytoplasm during serum starvation, indicating a dynamic role in cellular signaling and transcriptional regulation. This ability to shift between cellular compartments suggests ASC-1 is integral to forming distinct co-activator complexes that respond to varying cellular environments, thereby influencing transcriptional landscape and cellular responses to external stimuli. Anti-ASC-1 antibody (D-4) serves as an essential tool for researchers studying transcriptional mechanisms and their implications in various biological processes.

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ASC-1 Antibody (D-4) References:

1. Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain.  |  Helboe, L., et al. 2003. Eur J Neurosci. 18: 2227-38. PMID: 14622183
2. Gastrin activates paracrine networks leading to induction of PAI-2 via MAZ and Asc-1.  |  Almeida-Vega, S., et al. 2009. Am J Physiol Gastrointest Liver Physiol. 296: G414-23. PMID: 19074642
3. The transcription coactivator Asc-1 is a regulator of skeletal myogenesis, and its deficiency causes a novel form of congenital muscle disease.  |  Davignon, L., et al. 2016. Hum Mol Genet. 25: 1559-73. PMID: 27008887
4. The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons.  |  Ehmsen, JT., et al. 2016. Sci Rep. 6: 35592. PMID: 27759100
5. A neuronal role of the Alanine-Serine-Cysteine-1 transporter (SLC7A10, Asc-1) for glycine inhibitory transmission and respiratory pattern.  |  Mesuret, G., et al. 2018. Sci Rep. 8: 8536. PMID: 29867218
6. The Asc-1 Complex Disassembles Collided Ribosomes.  |  Juszkiewicz, S., et al. 2020. Mol Cell. 79: 603-614.e8. PMID: 32579943
7. Asc-1 regulates white versus beige adipocyte fate in a subcutaneous stromal cell population.  |  Suwandhi, L., et al. 2021. Nat Commun. 12: 1588. PMID: 33707431
8. Asc-1 transporter-dependent amino acid uptake is required for the efficient thermogenic response of human adipocytes to adrenergic stimulation.  |  Arianti, R., et al. 2021. FEBS Lett. 595: 2085-2098. PMID: 34197627
9. Amino acid transporter Asc-1 (SLC7A10) expression is altered in basal ganglia in experimental Parkinsonism and L-dopa-induced dyskinesia model mice.  |  Nakahara, K., et al. 2023. J Chem Neuroanat. 127: 102191. PMID: 36403747
10. The Asc-1 complex promotes translation initiation by scanning ribosomes.  |  Kito, Y., et al. 2023. EMBO J. 42: e112869. PMID: 37092320

The preferred ASC-1 antibody is ASC-1 Antibody (F-8): sc-365202.