ART2 Antibody (A-2): sc-515135
- ART2 Antibody (A-2) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against amino acids 41-130 mapping near the N-terminus of ART2 of mouse origin
- recommended for detection of ART2 of and mouse origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for ART2 Antibody (A-2) for WB applications. This reagent is now offered in a bundle with ART2 Antibody (A-2) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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ART2 Antibody (A-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects ART2 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ART2 (A-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ART2 plays a crucial role in the process of mono-ADP-ribosylation, a significant post-translational modification that regulates cellular metabolism, particularly in prokaryotes. This modification involves the transfer of the ADP-ribose moiety from nicotinamide adenine dinucleotide to specific amino acids on target proteins, influencing various cellular functions. ART2 is one of five mammalian ADP-ribosyltransferases, with expression primarily in tissues such as cardiac and skeletal muscle, leukocytes, brain, and testis. ART2 functions on the cell surface of mouse T lymphocytes as a glycosyl-phosphatidylinositol (GPI)-anchored ectoenzyme, suggesting involvement in modulating immune responses and cell signaling pathways. Understanding ART2 function and role in post-translational modifications is essential for elucidating impact on cell-matrix and cell-cell interactions, particularly in immune cell activation and tissue response.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ART2 Antibody (A-2) References:
- Characterization of glycosylphosphatidylinositiol-anchored, secreted, and intracellular vertebrate mono-ADP-ribosyltransferases. | Okazaki, IJ. and Moss, J. 1999. Annu Rev Nutr. 19: 485-509. PMID: 10448534
- Immunological and structural conservation of mammalian skeletal muscle glycosylphosphatidylinositol-linked ADP-ribosyltransferases. | Okazaki, IJ., et al. 1994. Biochemistry. 33: 12828-36. PMID: 7947688
- Assignment of the human and mouse genes for muscle ecto mono (ADPribosyl)transferase to a conserved linkage group on human chromosome 11p15 and mouse chromosome 7. | Koch-Nolte, F., et al. 1996. Genomics. 36: 215-6. PMID: 8812442
- Two novel human members of an emerging mammalian gene family related to mono-ADP-ribosylating bacterial toxins. | Koch-Nolte, F., et al. 1997. Genomics. 39: 370-6. PMID: 9119374
- Molecular characterization and expression of the gene for mouse NAD+:arginine ecto-mono(ADP-ribosyl)transferase, Art1. | Braren, R., et al. 1998. Biochem J. 336 (Pt 3): 561-8. PMID: 9841866
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ART2 Antibody (A-2) | sc-515135 | 200 µg/ml | $322.00 | |||
ART2 Antibody (A-2): m-IgGκ BP-HRP Bundle | sc-524950 | 200 µg Ab, 40 µg BP | $361.00 |