Arnt 1 Antibody (H1beta234): sc-56620

Arnt 1 Antibody (H1beta234) is a mouse monoclonal IgG1 antibody that detects Arnt 1 in mouse, rat, human, and bovine samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Arnt 1, also known as aryl hydrocarbon receptor nuclear translocator, plays a crucial role in cellular signaling as a transcription factor that mediates the effects of environmental toxins and endogenous signals by forming heterodimers with the aromatic hydrocarbon receptor (AhR). This interaction is vital for the regulation of genes involved in xenobiotic metabolism, including those encoding cytochrome P450 enzymes, which are essential for detoxifying harmful compounds. Anti-Arnt 1 antibody (H1beta234) recognizes nuclear localization, where Arnt 1 facilitates AhR binding to specific DNA sequences known as xenobiotic responsive elements (XREs), thereby influencing gene expression. The protein′s structure, characterized by its basic helix-loop-helix motif and PAS domains, is essential for dimerization and DNA-binding capabilities, underscoring Arnt 1′s importance in maintaining cellular homeostasis and responding to environmental changes. Arnt 1 monoclonal antibody (H1beta234) serves as an invaluable tool for researchers studying molecular mechanisms of transcriptional regulation and cellular response to environmental stressors.

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Arnt 1 Antibody (H1beta234) References:

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2. Metabolic changes detected by in vivo magnetic resonance studies of HEPA-1 wild-type tumors and tumors deficient in hypoxia-inducible factor-1beta (HIF-1beta): evidence of an anabolic role for the HIF-1 pathway.  |  Griffiths, JR., et al. 2002. Cancer Res. 62: 688-95. PMID: 11830521
3. Regulation of glucose metabolism-related genes and VEGF by HIF-1alpha and HIF-1beta, but not HIF-2alpha, in gastric cancer.  |  Song, IS., et al. 2009. Exp Mol Med. 41: 51-8. PMID: 19287200
4. HIF-1beta determines ABCA1 expression under hypoxia in human macrophages.  |  Ugocsai, P., et al. 2010. Int J Biochem Cell Biol. 42: 241-52. PMID: 19828131
5. MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta.  |  Cao, P., et al. 2010. Mol Cancer. 9: 108. PMID: 20478051
6. IFN-γ attenuates hypoxia-inducible factor (HIF) activity in intestinal epithelial cells through transcriptional repression of HIF-1β.  |  Glover, LE., et al. 2011. J Immunol. 186: 1790-8. PMID: 21199896
7. Clock-controlled output gene Dbp is a regulator of Arnt/Hif-1β gene expression in pancreatic islet β-cells.  |  Nakabayashi, H., et al. 2013. Biochem Biophys Res Commun. 434: 370-5. PMID: 23567972
8. MicroRNA-103/107 is involved in hypoxia-induced proliferation of pulmonary arterial smooth muscle cells by targeting HIF-1β.  |  Deng, B., et al. 2016. Life Sci. 147: 117-24. PMID: 26827991
9. MiR-107 suppresses cell proliferation and tube formation of Ewing sarcoma cells partly by targeting HIF-1β.  |  Chen, J., et al. 2018. Hum Cell. 31: 42-49. PMID: 29075999
10. Next Generation SICLOPPS Screening for the Identification of Inhibitors of the HIF-1α/HIF-1β Protein-Protein Interaction.  |  McDermott, A., et al. 2024. ACS Chem Biol. 19: 2232-2239. PMID: 39312747

The preferred Arnt 1 antibody is Arnt 1 Antibody (A-3): sc-17811.