ARMS Antibody (26): sc-136462

ARMS Antibody (26) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARMS protein of human, rat, and mouse origin by western blotting (WB) and immunoprecipitation (IP). Anti-ARMS antibody (26) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). The ankyrin repeat-rich membrane-spanning protein (ARMS), also known as kinase D-interacting substance 220 or Kidins220, is a highly conserved protein consisting of 1715 amino acids and features multiple domains, including four putative transmembrane domains and several ankyrin repeats. ARMS plays a crucial role in cellular signaling, particularly as a substrate for protein kinase D, and acts as a downstream target for neurotrophin (Trk) and ephrin (Eph) receptors. ARMS expression is notably concentrated in regions of the brain and neuroendocrine cells, where ARMS is found at the tips of neurites, highlighting ARMS importance in neuronal development and plasticity. ARMS is also detected in peripheral blood immature dendritic cells and PC12 cells, indicating ARMS involvement in various cellular processes. The gene encoding ARMS is located on chromosome 2p24, and ARMS evolutionary conservation suggests a fundamental role in cellular communication and signaling pathways across species.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

ARMS Antibody (26) References:

1. Identification and cloning of Kidins220, a novel neuronal substrate of protein kinase D.  |  Iglesias, T., et al. 2000. J Biol Chem. 275: 40048-56. PMID: 10998417
2. An evolutionarily conserved transmembrane protein that is a novel downstream target of neurotrophin and ephrin receptors.  |  Kong, H., et al. 2001. J Neurosci. 21: 176-85. PMID: 11150334
3. The neuronal protein Kidins220 localizes in a raft compartment at the leading edge of motile immature dendritic cells.  |  Riol-Blanco, L., et al. 2004. Eur J Immunol. 34: 108-18. PMID: 14971036
4. A unique pathway for sustained neurotrophin signaling through an ankyrin-rich membrane-spanning protein.  |  Arévalo, JC., et al. 2004. EMBO J. 23: 2358-68. PMID: 15167895
5. {alpha}-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner.  |  Luo, S., et al. 2005. J Cell Biol. 169: 813-24. PMID: 15939763
6. SPATA2 - Keeping the TNF signal short and sweet.  |  Feltham, R., et al. 2016. EMBO J. 35: 1848-50. PMID: 27470000
7. Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice.  |  Zhao, J., et al. 2017. Biol Reprod. 97: 497-513. PMID: 29025062
8. PLK4 deubiquitination by Spata2-CYLD suppresses NEK7-mediated NLRP3 inflammasome activation at the centrosome.  |  Yang, XD., et al. 2020. EMBO J. 39: e102201. PMID: 31762063
9. TNFα signalling predicts poor prognosis of patients with endometrial cancer.  |  Wieser, V., et al. 2020. Carcinogenesis. 41: 1065-1073. PMID: 32301486
10. Genotoxicity-Stimulated and CYLD-Driven Malignant Transformation.  |  Erol, A. 2022. Cancer Manag Res. 14: 2339-2356. PMID: 35958947
11. Identification of a Novel Hypoxia-induced Inflammatory Cell Death Pathway.  |  Bhardwaj, A., et al. 2023. bioRxiv.. PMID: 37808759
12. A mechanism for hypoxia-induced inflammatory cell death in cancer.  |  Bhardwaj, A., et al. 2025. Nature. 637: 470-477. PMID: 39506105

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARMS Antibody (26) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-ARMS Antibody (26) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARMS Antibody (26) Specifications

Alternate Product Name: ARMS

Product Clone Name: 26

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1567-1757

Epitope Target: ARMS

Epitope Species: rat

Product Reactivity/Detection: ARMS of human and rat origin and KIDINS220 of mouse origin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for ARMS Antibody (26): AC: Agarose, HRP: Horseradish Peroxidase