ARMER Antibody (E-8): sc-514227
- ARMER Antibody (E-8) is a mouse monoclonal mouse IgG1 κ κ provided at 200 µg/ml
- raised against amino acids 1-115 mapping at the N-terminus of ARMER of human origin
- recommended for detection of ARMER of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ARMER Antibody (E-8) for WB applications. These reagents are now offered in bundles with ARMER Antibody (E-8) (see ordering information below).
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ARMER Antibody (E-8) is a mouse monoclonal IgG1 antibody that detects ARMER in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). ARMER, also known as ADP-ribosylation-like factor 6-interacting protein 1 (ARL6IP1 or AIP1), is a multi-pass membrane protein belonging to the Ras superfamily, primarily expressed in the brain, thymus, lung, and bone marrow, with lower expression levels in spleen, kidney, and liver. Notably absent in heart, ARMER is predominantly localized in early myeloid progenitor cells, where ARMER resides within intracytoplasmic membranes. ARMER plays a crucial role in regulating apoptosis by interacting with ARL6 and inhibiting caspase-9 activity, which is vital for preventing unwanted cell death during hematopoietic maturation. Inhibition of caspase-9 leads to prevention of proteolysis of downstream substrates, including vimentin and caspase-3, thereby influencing membrane trafficking, protein transport, and cell signaling pathways. Anti-ARMER antibody (E-8) is an essential tool for researchers investigating mechanisms of apoptosis and myeloid differentiation, providing insights into complex processes that govern cell survival and development.
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ARMER Antibody (E-8) References:
- ARMER, apoptotic regulator in the membrane of the endoplasmic reticulum, a novel inhibitor of apoptosis. | Lui, HM., et al. 2003. Mol Cancer Res. 1: 508-18. PMID: 12754298
- Non-peptidic GnRH receptor antagonists. | Armer, RE. and Smelt, KH. 2004. Curr Med Chem. 11: 3017-28. PMID: 15544487
- Post-breast cancer. Lymphedema: part 1. | Fu, MR., et al. 2009. Am J Nurs. 109: 48-54; quiz 55. PMID: 19546644
- Pluripotency-associated genes in human nasopharyngeal carcinoma CNE-2 cells are reactivated by a unique epigenetic sub-microenvironment. | Cao, JX., et al. 2010. BMC Cancer. 10: 68. PMID: 20181293
- Intermittent pneumatic compression therapy: a systematic review. | Feldman, JL., et al. 2012. Lymphology. 45: 13-25. PMID: 22768469
- Complementary and alternative medicine and lymphedema. | Wanchai, A., et al. 2013. Semin Oncol Nurs. 29: 41-9. PMID: 23375065
- Recent progress in the treatment and prevention of cancer-related lymphedema. | Shaitelman, SF., et al. 2015. CA Cancer J Clin. 65: 55-81. PMID: 25410402
- Decision making in pediatric hematopoietic cell transplantation: Influential factors vary among diseases. | Schulz, GL., et al. 2018. Pediatr Blood Cancer. 65: PMID: 29218777
- Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial. | Thwaites, GE., et al. 2018. Lancet. 391: 668-678. PMID: 29249276
- Quality assurance for the NHS abdominal aortic aneurysm screening programme in England. | Campbell, A., et al. 2022. BJS Open. 6: PMID: 35143623
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARMER Antibody (E-8) | sc-514227 | 200 µg/ml | $322.00 | |||
ARMER Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-540966 | 200 µg Ab; 10 µg BP | $361.00 | |||
ARMER Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-542497 | 200 µg Ab; 20 µg BP | $361.00 |