ARID3B Antibody (C-6): sc-514741
- ARID3B Antibody (C-6) is a mouse monoclonal IgG1 κ ARID3B antibody provided at 200 µg/ml
- raised against amino acids 25-211 mapping near the N-terminus of ARID3B of human origin
- ARID3B Antibody (C-6) is recommended for detection of ARID3B isoforms 1, 3 and 4 of human origin by WB, IP, IF and ELISA
- Anti-ARID3B Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ARID3B Antibody (C-6) for WB applications. These reagents are now offered in bundles with ARID3B Antibody (C-6) (see ordering information below).
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ARID3B Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARID3B protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ARID3B antibody (C-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARID3B protein, also known as AT rich interactive domain 3B, DRIL2, or Bright-like in mice, is a crucial transcription factor that plays a significant role in regulating gene expression during cell lineage determination and embryonic development. ARID3B is primarily located in the nucleus, where ARID3B binds to DNA through its AT-rich interactive domain, facilitating the transcription of genes essential for neural crest survival during embryogenesis. ARID3B function is particularly important as ARID3B influences the development of various tissues and organs, and aberrations in ARID3B activity have been implicated in processes such as malignant transformation and neuroblastoma growth, highlighting ARID3B′s potential as a tumor marker for neuroblastoma. ARID3B′s ability to form heterodimers with ARID3A further underscores ARID3B′s importance in transcriptional regulation and cellular differentiation, making ARID3B (C-6) monoclonal antibody a valuable tool for researchers studying these critical biological processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ARID3B Antibody (C-6) References:
- Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product. | Numata, S., et al. 1999. Cancer Res. 59: 3741-7. PMID: 10446990
- ARID proteins come in from the desert. | Kortschak, RD., et al. 2000. Trends Biochem Sci. 25: 294-9. PMID: 10838570
- A regulated nucleocytoplasmic shuttle contributes to Bright's function as a transcriptional activator of immunoglobulin genes. | Kim, D. and Tucker, PW. 2006. Mol Cell Biol. 26: 2187-201. PMID: 16507996
- Microarray analysis of PDGFR alpha+ populations in ES cell differentiation culture identifies genes involved in differentiation of mesoderm and mesenchyme including ARID3b that is essential for development of embryonic mesenchymal cells. | Takebe, A., et al. 2006. Dev Biol. 293: 25-37. PMID: 16530748
- ARID3B induces malignant transformation of mouse embryonic fibroblasts and is strongly associated with malignant neuroblastoma. | Kobayashi, K., et al. 2006. Cancer Res. 66: 8331-6. PMID: 16951138
- A novel ARID/Bright-like protein involved in transcriptional activation of cyst wall protein 1 gene in Giardia lamblia. | Wang, CH., et al. 2007. J Biol Chem. 282: 8905-14. PMID: 17244608
- REKLES is an ARID3-restricted multifunctional domain. | Kim, D., et al. 2007. J Biol Chem. 282: 15768-77. PMID: 17400556
- The human dead ringer/bright homolog, DRIL1: cDNA cloning, gene structure, and mapping to D19S886, a marker on 19p13.3 that is strictly linked to the Peutz-Jeghers syndrome. | Kortschak, RD., et al. 1998. Genomics. 51: 288-92. PMID: 9722953
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARID3B Antibody (C-6) | sc-514741 | 200 µg/ml | $322.00 | |||
ARID3B Antibody (C-6): m-IgG Fc BP-HRP Bundle | sc-531213 | 200 µg Ab; 10 µg BP | $361.00 | |||
ARID3B Antibody (C-6): m-IgGκ BP-HRP Bundle | sc-524835 | 200 µg Ab, 40 µg BP | $361.00 | |||
ARID3B Antibody (C-6): m-IgG1 BP-HRP Bundle | sc-544437 | 200 µg Ab; 20 µg BP | $361.00 | |||
ARID3B Antibody (C-6) AC | sc-514741 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ARID3B Antibody (C-6) HRP | sc-514741 HRP | 200 µg/ml | $322.00 | |||
ARID3B Antibody (C-6) FITC | sc-514741 FITC | 200 µg/ml | $336.00 | |||
ARID3B Antibody (C-6) PE | sc-514741 PE | 200 µg/ml | $349.00 | |||
ARID3B Antibody (C-6) Alexa Fluor® 488 | sc-514741 AF488 | 200 µg/ml | $364.00 | |||
ARID3B Antibody (C-6) Alexa Fluor® 546 | sc-514741 AF546 | 200 µg/ml | $364.00 | |||
ARID3B Antibody (C-6) Alexa Fluor® 594 | sc-514741 AF594 | 200 µg/ml | $364.00 | |||
ARID3B Antibody (C-6) Alexa Fluor® 647 | sc-514741 AF647 | 200 µg/ml | $364.00 | |||
ARID3B Antibody (C-6) Alexa Fluor® 680 | sc-514741 AF680 | 200 µg/ml | $364.00 | |||
ARID3B Antibody (C-6) Alexa Fluor® 790 | sc-514741 AF790 | 200 µg/ml | $364.00 |