ARID2 Antibody (E-3): sc-166117

ARID2 Antibody (E-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARID2 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). ARID2 (E-3) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARID2 protein, also known as BAF200 (AT-rich interactive domain-containing protein 2), is a crucial 1,835 amino acid nuclear protein encoded by the human gene ARID2. ARID2 plays a significant role in chromatin remodeling as a member of the SWI/SNF family of complexes, which are essential for regulating gene expression through the alteration of DNA-nucleosome topology. ARID2 is involved in the stability and function of both the BAF (SWI/SNF-A) and PBAF (SWI/SNF-B) complexes, which are vital for transcriptional activation and repression of specific genes. ARID2′s ability to interact with various transcription factors and other chromatin-associated proteins underscores ARID2′s importance in cellular processes such as differentiation, development, and response to environmental signals. Understanding ARID2 function and interactions can provide insights into ARID2′s role in various diseases, including cancer, where chromatin remodeling is often disrupted.

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ARID2 Antibody (E-3) References:

1. Mechanisms for ATP-dependent chromatin remodelling.  |  Whitehouse, I., et al. 2000. Biochem Soc Trans. 28: 376-9. PMID: 10961923
2. Recent advances in understanding chromatin remodeling by Swi/Snf complexes.  |  Martens, JA. and Winston, F. 2003. Curr Opin Genet Dev. 13: 136-42. PMID: 12672490
3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).  |  Gerhard, DS., et al. 2004. Genome Res. 14: 2121-7. PMID: 15489334
4. DNA-binding properties of ARID family proteins.  |  Patsialou, A., et al. 2005. Nucleic Acids Res. 33: 66-80. PMID: 15640446
5. Nomenclature of the ARID family of DNA-binding proteins.  |  Wilsker, D., et al. 2005. Genomics. 86: 242-51. PMID: 15922553
6. PBAF chromatin-remodeling complex requires a novel specificity subunit, BAF200, to regulate expression of selective interferon-responsive genes.  |  Yan, Z., et al. 2005. Genes Dev. 19: 1662-7. PMID: 15985610
7. Zipzap/p200 is a novel zinc finger protein contributing to cardiac gene regulation.  |  Zhang, X., et al. 2006. Biochem Biophys Res Commun. 346: 794-801. PMID: 16782067
8. Long non-coding RNA Arid2-IR affects advanced glycation end products-induced human retinal endothelial cell injury by binding to Smad3.  |  Xiao, H., et al. 2020. Int Ophthalmol. 40: 1123-1133. PMID: 31912402
9. ARID2 is a pomalidomide-dependent CRL4CRBN substrate in multiple myeloma cells.  |  Yamamoto, J., et al. 2020. Nat Chem Biol. 16: 1208-1217. PMID: 32958952
10. ARID1A, ARID1B, and ARID2 Mutations Serve as Potential Biomarkers for Immune Checkpoint Blockade in Patients With Non-Small Cell Lung Cancer.  |  Zhu, G., et al. 2021. Front Immunol. 12: 670040. PMID: 34512623
11. ARID2 suppression promotes tumor progression and upregulates cytokeratin 8, 18 and β-4 integrin expression in TP53-mutated tobacco-related oral cancer and has prognostic implications.  |  Shukla, P., et al. 2022. Cancer Gene Ther. 29: 1908-1917. PMID: 35869277
12. Arid2-IR downregulates miR-132-3p through methylation to promote LPS-induced ALI in pneumonia.  |  Liu, Y., et al. 2022. Inhal Toxicol. 34: 297-303. PMID: 36074605

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARID2 Antibody (E-3) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-ARID2 Antibody (E-3) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARID2 Antibody (E-3) Specifications

Alternate Product Name: ARID2

Product Clone Name: E-3

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1134-1316

Epitope Target: ARID2

Epitope Species: human

Product Reactivity/Detection: ARID2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for ARID2 Antibody (E-3): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent