ARHGEF9 Antibody (3): sc-136393
- ARHGEF9 Antibody (3) is a mouse monoclonal IgG1 κ ARHGEF9 antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 18-131 of ARHGEF9 of rat origin
- recommended for detection of ARHGEF9 of mouse, rat and human origin by WB and IP
- available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ARHGEF9 Antibody (3) for WB applications. These reagents are now offered in bundles with ARHGEF9 Antibody (3) (see ordering information below).
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ARHGEF9 Antibody (3) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARHGEF9 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-ARHGEF9 antibody (3) is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). ARHGEF9, also known as Rho guanine nucleotide exchange factor 9, PEM-2 homolog, or Collybistin, is a crucial 516 amino acid cytoplasmic protein that plays a significant role in neuronal signaling. ARHGEF9 functions as a guanine nucleotide exchange factor for Cdc42, a member of the Rho family of GTPases, which is essential for regulating the actin cytoskeleton and promoting the formation of Gephyrin clusters, thereby facilitating inhibitory synapse development. ARHGEF9 is vital for maintaining proper synaptic function and plasticity, and defects in the gene encoding ARHGEF9 are implicated in startle disease with epilepsy (STHEE), a heterogeneous neurological disorder characterized by muscular rigidity and exaggerated startle responses to sensory stimuli. Understanding ARHGEF9′s role in synaptic organization and interactions with proteins like Gephyrin is crucial for elucidating the mechanisms underlying various neurological conditions.
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ARHGEF9 Antibody (3) References:
- Identification and characterization of hPEM-2, a guanine nucleotide exchange factor specific for Cdc42. | Reid, T., et al. 1999. J Biol Chem. 274: 33587-93. PMID: 10559246
- Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin. | Grosskreutz, Y., et al. 2001. Biol Chem. 382: 1455-62. PMID: 11727829
- The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. | Harvey, K., et al. 2004. J Neurosci. 24: 5816-26. PMID: 15215304
- ARHGEF9 disruption in a female patient is associated with X linked mental retardation and sensory hyperarousal. | Marco, EJ., et al. 2008. J Med Genet. 45: 100-5. PMID: 17893116
- Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway. | Yamaguchi, K., et al. 2008. Biol Chem. 389: 405-13. PMID: 18208356
- Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. | Ishikawa, K., et al. 1997. DNA Res. 4: 307-13. PMID: 9455477
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARHGEF9 Antibody (3) | sc-136393 | 200 µg/ml | $322.00 | |||
ARHGEF9 Antibody (3): m-IgG Fc BP-HRP Bundle | sc-528820 | 200 µg Ab; 10 µg BP | $361.00 | |||
ARHGEF9 Antibody (3): m-IgGκ BP-HRP Bundle | sc-521364 | 200 µg Ab, 40 µg BP | $361.00 | |||
ARHGEF9 Antibody (3): m-IgG1 BP-HRP Bundle | sc-543151 | 200 µg Ab; 20 µg BP | $361.00 | |||
ARHGEF9 Antibody (3) AC | sc-136393 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ARHGEF9 Antibody (3) HRP | sc-136393 HRP | 200 µg/ml | $322.00 |