ARHGAP29 Antibody (H-2): sc-377022

ARHGAP29 Antibody (H-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARHGAP29 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). ARHGAP29 (H-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARHGAP29, also known as Rho GTPase activating protein 29 or PARG1, is a 1,261 amino acid protein that plays a crucial role in cellular signaling by regulating Rho-type GTPases. ARHGAP29 contains a phorbol-ester/DAG-type zinc finger and a Rho-GAP domain, which are essential for function as a GTPase-activating protein. ARHGAP29 is predominantly expressed in skeletal muscle and heart, with intermediate levels in placenta, liver, and pancreas, and lower levels in brain, lung, and kidney. By converting Rho-type GTPases to their inactive GDP-bound state, ARHGAP29 effectively down-regulates active forms, particularly showing strong activity towards Rho A and weaker activity towards Rac 1 and Cdc42. ARHGAP29 is recognized as a specific effector of Rap 2A, further highlighting importance in regulating Rho signaling pathways. ARHGAP29 is down-regulated in mantle-cell lymphomas and up-regulated in migrating glioma cells, indicating potential role in cancer biology. ARHGAP29 exists as two alternatively spliced isoforms, which may contribute to diverse functional roles in different cellular contexts.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ARHGAP29 Antibody (H-2) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-ARHGAP29 Antibody (H-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ARHGAP29 Antibody (H-2) Specifications

Alternate Product Name: ARHGAP29

Product Clone Name: H-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 881-1180

Epitope Target: ARHGAP29

Epitope Species: mouse

Product Reactivity/Detection: ARHGAP29

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for ARHGAP29 Antibody (H-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred ARHGAP29 antibody is ARHGAP29 Antibody (D-3): sc-365554.