ARHGAP29 Antibody (D-3): sc-365554
- ARHGAP29 Antibody (D-3) is a mouse monoclonal IgG1 κ ARHGAP29 antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 881-1180 mapping within an internal region of ARHGAP29 of human origin
- ARHGAP29 Antibody (D-3) is recommended for detection of ARHGAP29 of human origin by WB, IP, IF and ELISA
- Anti-ARHGAP29 Antibody (D-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for ARHGAP29 Antibody (D-3) for WB applications. These reagents are now offered in bundles with ARHGAP29 Antibody (D-3) (see ordering information below).
ARHGAP29 Antibody (D-3) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARHGAP29 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-ARHGAP29 antibody (D-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARHGAP29, also known as Rho GTPase activating protein 29 or PARG1, is a 1,261 amino acid protein that plays a crucial role in cellular signaling by regulating the activity of Rho-type GTPases. Such regulation is vital because Rho GTPases are involved in various cellular processes, including cytoskeletal dynamics, cell migration, and proliferation. ARHGAP29 contains a phorbol-ester/DAG-type zinc finger and a Rho-GAP domain, and is predominantly expressed in skeletal muscle and heart, with intermediate levels in placenta, liver, and pancreas, and lower levels in brain, lung, and kidney. As a GTPase activator, ARHGAP29 facilitates the conversion of Rho GTPases to their inactive GDP-bound state, exhibiting strong activity towards Rho A and weaker activity towards Rac 1 and Cdc42. ARHGAP29 is recognized as a specific effector of Rap 2A, further emphasizing its role in the regulation of Rho signaling pathways. ARHGAP29 expression is significantly down-regulated in mantle-cell lymphomas and up-regulated in migrating glioma cells, highlighting its potential involvement in cancer biology. ARHGAP29 also exists in two alternatively spliced isoforms, which may contribute to its functional diversity in different cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ARHGAP29 Antibody (D-3) References:
- ARHGAP10, a novel human gene coding for a potentially cytoskeletal Rho-GTPase activating protein. | Bassères, DS., et al. 2002. Biochem Biophys Res Commun. 294: 579-85. PMID: 12056806
- Poly(ADP-ribose) polymerases: managing genome stability. | Meyer-Ficca, ML., et al. 2005. Int J Biochem Cell Biol. 37: 920-6. PMID: 15743666
- PARG1, a protein-tyrosine phosphatase-associated RhoGAP, as a putative Rap2 effector. | Myagmar, BE., et al. 2005. Biochem Biophys Res Commun. 329: 1046-52. PMID: 15752761
- Promoter methylation of PARG1, a novel candidate tumor suppressor gene in mantle-cell lymphomas. | Ripperger, T., et al. 2007. Haematologica. 92: 460-8. PMID: 17488656
- Integrated genomic and expression profiling in mantle cell lymphoma: identification of gene-dosage regulated candidate genes. | Schraders, M., et al. 2008. Br J Haematol. 143: 210-21. PMID: 18699851
- Gene expression profiling of alpha-radiation-induced rat osteosarcomas: identification of dysregulated genes involved in radiation-induced tumorigenesis of bone. | Daino, K., et al. 2009. Int J Cancer. 125: 612-20. PMID: 19444910
- Cancer-related transcriptional targets of the circadian gene NPAS2 identified by genome-wide ChIP-on-chip analysis. | Yi, CH., et al. 2009. Cancer Lett. 284: 149-56. PMID: 19457610
- A novel GTPase-activating protein for Rho interacts with a PDZ domain of the protein-tyrosine phosphatase PTPL1. | Saras, J., et al. 1997. J Biol Chem. 272: 24333-8. PMID: 9305890
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARHGAP29 Antibody (D-3) | sc-365554 | 200 µg/ml | $322.00 | |||
ARHGAP29 Antibody (D-3): m-IgG Fc BP-HRP Bundle | sc-527380 | 200 µg Ab; 10 µg BP | $361.00 | |||
ARHGAP29 Antibody (D-3): m-IgG1 BP-HRP Bundle | sc-532753 | 200 µg Ab; 20 µg BP | $361.00 | |||
ARHGAP29 Antibody (D-3) AC | sc-365554 AC | 500 µg/ml, 25% agarose | $424.00 | |||
ARHGAP29 Antibody (D-3) HRP | sc-365554 HRP | 200 µg/ml | $322.00 | |||
ARHGAP29 Antibody (D-3) FITC | sc-365554 FITC | 200 µg/ml | $336.00 | |||
ARHGAP29 Antibody (D-3) PE | sc-365554 PE | 200 µg/ml | $349.00 | |||
ARHGAP29 Antibody (D-3) Alexa Fluor® 488 | sc-365554 AF488 | 200 µg/ml | $364.00 | |||
ARHGAP29 Antibody (D-3) Alexa Fluor® 546 | sc-365554 AF546 | 200 µg/ml | $364.00 | |||
ARHGAP29 Antibody (D-3) Alexa Fluor® 594 | sc-365554 AF594 | 200 µg/ml | $364.00 | |||
ARHGAP29 Antibody (D-3) Alexa Fluor® 647 | sc-365554 AF647 | 200 µg/ml | $364.00 | |||
ARHGAP29 Antibody (D-3) Alexa Fluor® 680 | sc-365554 AF680 | 200 µg/ml | $364.00 | |||
ARHGAP29 Antibody (D-3) Alexa Fluor® 790 | sc-365554 AF790 | 200 µg/ml | $364.00 |