ARHGAP1 Antibody (C-10): sc-398671
- ARHGAP1 Antibody (C-10) is a mouse monoclonal IgG1 κ ARHGAP1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 24-55 within an internal region of ARHGAP1 of human origin
- ARHGAP1 Antibody (C-10) is recommended for detection of ARHGAP1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-ARHGAP1 Antibody (C-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ARHGAP1 Antibody (C-10) for WB applications. These reagents are now offered in bundles with ARHGAP1 Antibody (C-10) (see ordering information below).
ARHGAP1 Antibody (C-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ARHGAP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-ARHGAP1 antibody (C-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARHGAP1, also known as Rho GTPase activating protein 1, plays a crucial role in cellular signaling by regulating Rho family GTPases activity, which are essential for various cellular processes such as cytoskeletal dynamics, cell migration, and proliferation. Specifically, ARHGAP1 accelerates intrinsic GTP hydrolysis of these GTPases, leading to their inactivation and thus modulating pathways vital for maintaining normal cellular functions. ARHGAP1 consists of 439 amino acids and is characterized by one Rho-GAP domain and one CRAL-TRIO domain, which are important for GTPase-activating activity. ARHGAP1 is predominantly localized in cytoplasm and is expressed in various tissues, indicating a fundamental role in cellular homeostasis. ARHGAP1 interacts with several other proteins, including eIF4AI and Exportin 7, further highlighting involvement in complex cellular networks. ARHGAP1 gene is located on human chromosome 11, a region associated with several genetic disorders, underscoring importance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ARHGAP1 Antibody (C-10) References:
- BNIP-2 induces cell elongation and membrane protrusions by interacting with Cdc42 via a unique Cdc42-binding motif within its BNIP-2 and Cdc42GAP homology domain. | Zhou, YT., et al. 2005. Exp Cell Res. 303: 263-74. PMID: 15652341
- p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho. | Wildenberg, GA., et al. 2006. Cell. 127: 1027-39. PMID: 17129786
- Differential gene expression analysis of tubule forming and non-tubule forming endothelial cells: CDC42GAP as a counter-regulator in tubule formation. | Engelse, MA., et al. 2008. Angiogenesis. 11: 153-67. PMID: 18060510
- Nudel binds Cdc42GAP to modulate Cdc42 activity at the leading edge of migrating cells. | Shen, Y., et al. 2008. Dev Cell. 14: 342-53. PMID: 18331715
- Bcr encodes a GTPase-activating protein for p21rac. | Diekmann, D., et al. 1991. Nature. 351: 400-2. PMID: 1903516
- Purification and N-terminal sequence of the p21rho GTPase-activating protein, rho GAP. | Garrett, MD., et al. 1991. Biochem J. 276 (Pt 3): 833-6. PMID: 1905930
- Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain. | Barfod, ET., et al. 1993. J Biol Chem. 268: 26059-62. PMID: 8253717
- Characterization of rhoGAP. A GTPase-activating protein for rho-related small GTPases. | Lancaster, CA., et al. 1994. J Biol Chem. 269: 1137-42. PMID: 8288572
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARHGAP1 Antibody (C-10) | sc-398671 | 200 µg/ml | $316.00 | |||
ARHGAP1 Antibody (C-10): m-IgG Fc BP-HRP Bundle | sc-530897 | 200 µg Ab; 10 µg BP | $354.00 | |||
ARHGAP1 Antibody (C-10): m-IgGκ BP-HRP Bundle | sc-524448 | 200 µg Ab, 40 µg BP | $354.00 | |||
ARHGAP1 Antibody (C-10): m-IgG1 BP-HRP Bundle | sc-544307 | 200 µg Ab; 20 µg BP | $354.00 | |||
ARHGAP1 Antibody (C-10) AC | sc-398671 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ARHGAP1 Antibody (C-10) HRP | sc-398671 HRP | 200 µg/ml | $316.00 | |||
ARHGAP1 Antibody (C-10) FITC | sc-398671 FITC | 200 µg/ml | $330.00 | |||
ARHGAP1 Antibody (C-10) PE | sc-398671 PE | 200 µg/ml | $343.00 | |||
ARHGAP1 Antibody (C-10) Alexa Fluor® 488 | sc-398671 AF488 | 200 µg/ml | $357.00 | |||
ARHGAP1 Antibody (C-10) Alexa Fluor® 546 | sc-398671 AF546 | 200 µg/ml | $357.00 | |||
ARHGAP1 Antibody (C-10) Alexa Fluor® 594 | sc-398671 AF594 | 200 µg/ml | $357.00 | |||
ARHGAP1 Antibody (C-10) Alexa Fluor® 647 | sc-398671 AF647 | 200 µg/ml | $357.00 | |||
ARHGAP1 Antibody (C-10) Alexa Fluor® 680 | sc-398671 AF680 | 200 µg/ml | $357.00 | |||
ARHGAP1 Antibody (C-10) Alexa Fluor® 790 | sc-398671 AF790 | 200 µg/ml | $357.00 | |||
ARHGAP1 (C-10) Neutralizing Peptide | sc-398671 P | 100 µg/0.5 ml | $68.00 |