Arg Antibody (1H1B11): sc-81154
- Arg Antibody (1H1B11) is a mouse monoclonal IgG1 κ Arg antibody, cited in 2 publications, provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 54-268 of Arg of human origin
- Arg Antibody (1H1B11) is recommended for detection of Arg of mouse, rat and human origin by WB, IP and IF
- Anti-Arg Antibody (1H1B11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Arg Antibody (1H1B11) for WB applications. These reagents are now offered in bundles with Arg Antibody (1H1B11) (see ordering information below).
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Arg Antibody (1H1B11) is a mouse monoclonal IgG1 kappa light chain antibody that detects the Arg protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Anti-Arg antibody (1H1B11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Arg protein, also known as Abl2, plays a crucial role in cellular signaling pathways, particularly in regulating cell growth and differentiation. Arg contains both SH2 and SH3 domains, which are essential for protein-protein interactions, allowing engagement with various signaling molecules. One significant interaction is with c-Crk, a protein involved in regulating cytoskeletal dynamics and cell migration. Phosphorylation of c-Crk by Arg is vital for modulating these processes, which are important in development and immune responses. Dysregulation of Arg and its interactions can contribute to various pathologies, including cancer, making Arg (1H1B11) antibody a valuable tool for researchers studying these critical biological pathways.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Arg Antibody (1H1B11) References:
- The Abl-related gene (Arg) nonreceptor tyrosine kinase uses two F-actin-binding domains to bundle F-actin. | Wang, Y., et al. 2001. Proc Natl Acad Sci U S A. 98: 14865-70. PMID: 11752434
- Three-dimensional solution structure of the src homology 2 domain of c-abl. | Overduin, M., et al. 1992. Cell. 70: 697-704. PMID: 1505033
- The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. | Miller, AL., et al. 2004. J Cell Biol. 165: 407-19. PMID: 15138293
- The Abl-related gene tyrosine kinase acts through p190RhoGAP to inhibit actomyosin contractility and regulate focal adhesion dynamics upon adhesion to fibronectin. | Peacock, JG., et al. 2007. Mol Biol Cell. 18: 3860-72. PMID: 17652459
- Use of a chemical genetic technique to identify myosin IIb as a substrate of the Abl-related gene (Arg) tyrosine kinase. | Boyle, SN. and Koleske, AJ. 2007. Biochemistry. 46: 11614-20. PMID: 17892306
- Bcr encodes a GTPase-activating protein for p21rac. | Diekmann, D., et al. 1991. Nature. 351: 400-2. PMID: 1903516
- Abl2/Abl-related gene stabilizes actin filaments, stimulates actin branching by actin-related protein 2/3 complex, and promotes actin filament severing by cofilin. | Courtemanche, N., et al. 2015. J Biol Chem. 290: 4038-46. PMID: 25540195
- Evidence of a new chimeric bcr/c-abl mRNA in patients with chronic myelocytic leukemia and the Philadelphia chromosome. | Stam, K., et al. 1985. N Engl J Med. 313: 1429-33. PMID: 3864009
- Lymphosarcoma: virus-induced thymic-independent disease in mice. | Abelson, HT. and Rabstein, LS. 1970. Cancer Res. 30: 2213-22. PMID: 4318922
- Sequences of the A-MuLV protein needed for fibroblast and lymphoid cell transformation. | Prywes, R., et al. 1983. Cell. 34: 569-79. PMID: 6193890
- An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. | Konopka, JB., et al. 1984. Cell. 37: 1035-42. PMID: 6204766
- A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. | de Klein, A., et al. 1982. Nature. 300: 765-7. PMID: 6960256
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Arg Antibody (1H1B11) | sc-81154 | 200 µg/ml | $322.00 | |||
Arg Antibody (1H1B11): m-IgG Fc BP-HRP Bundle | sc-527055 | 200 µg Ab; 10 µg BP | $361.00 | |||
Arg Antibody (1H1B11): m-IgG1 BP-HRP Bundle | sc-532428 | 200 µg Ab; 20 µg BP | $361.00 | |||
Arg Antibody (1H1B11) AC | sc-81154 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Arg Antibody (1H1B11) HRP | sc-81154 HRP | 200 µg/ml | $322.00 | |||
Arg Antibody (1H1B11) FITC | sc-81154 FITC | 200 µg/ml | $336.00 | |||
Arg Antibody (1H1B11) PE | sc-81154 PE | 200 µg/ml | $349.00 | |||
Arg Antibody (1H1B11) Alexa Fluor® 488 | sc-81154 AF488 | 200 µg/ml | $364.00 | |||
Arg Antibody (1H1B11) Alexa Fluor® 546 | sc-81154 AF546 | 200 µg/ml | $364.00 | |||
Arg Antibody (1H1B11) Alexa Fluor® 594 | sc-81154 AF594 | 200 µg/ml | $364.00 | |||
Arg Antibody (1H1B11) Alexa Fluor® 647 | sc-81154 AF647 | 200 µg/ml | $364.00 | |||
Arg Antibody (1H1B11) Alexa Fluor® 680 | sc-81154 AF680 | 200 µg/ml | $364.00 | |||
Arg Antibody (1H1B11) Alexa Fluor® 790 | sc-81154 AF790 | 200 µg/ml | $364.00 |