Arc Antibody (H-6): sc-365736

Arc Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody engineered to recognize an epitope spanning amino acids 2-29 at the N-terminus of Arc protein, also known as activity-regulated cytoskeleton-associated protein or Arg3.1, derived from rat origin. Arc (H-6) antibody is effective for detecting Arc in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA) applications. Arc protein functions as a crucial immediate early gene involved in synaptic plasticity, learning, and memory by regulating the actin cytoskeleton within neuronal cells. Arc interacts with several key proteins, including Endophilin, Dynamin, and PICK1, which facilitate AMPA receptor endocytosis and modulate synaptic strength. These interactions are essential for synaptic remodeling and maintenance of neural network adaptability. Arc is predominantly localized in neuronal cell bodies and dendrites within key brain regions such as the hippocampus, amygdala, hypothalamus, striatum, and cortex, where Arc integrates signals from neuronal activity to drive structural and functional synaptic changes. Arc′s ability to engage with these interacting proteins underscores Arc′s importance in maintaining the dynamic architecture of dendritic spines, which is vital for adaptive neural network function. Additionally, Arc expression is rapidly induced by stimuli like growth factors and neurotransmitters, enabling Arc to mediate long-term cellular responses essential for cognitive processes. By utilizing anti-Arc antibody (H-6), researchers can effectively investigate protein-protein interactions and functional dynamics of Arc protein, thereby advancing the understanding of neural plasticity and its implications in neurological disorders.

The preferred Arc antibody is Arc Antibody (C-7): sc-17839.