Arc Antibody (C-7): sc-17839

Arc Antibody (C-7) is a mouse monoclonal IgG2a kappa light chain antibody designed to target the Arc protein, also known as activity-regulated cytoskeleton-associated protein or Arg3.1, by recognizing amino acids 1-300 of the human Arc protein. Anti-Arc antibody (C-7) can detect Arc across multiple species, including mouse, rat, and human, and is suitable for various applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). The Arc protein is a critical immediate early gene involved in synaptic plasticity, learning, and memory, playing a pivotal role in regulating the cytoskeleton and modulating synaptic strength in response to neuronal activity. Arc expression is rapidly induced by growth factors and neurotransmitters, facilitating long-term cellular responses and neuroplastic changes essential for cognitive functions. Arc is predominantly localized in neuronal cell bodies and dendrites within key brain regions like the hippocampus, amygdala, hypothalamus, striatum, and cortex, where Arc interacts with F-Actin and other actin-associated proteins to influence dendritic spine morphology and synaptic efficacy. Arc (C-7) antibody is available in both non-conjugated form and various conjugated variants, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatile tools for diverse experimental setups. Additionally, Arc expression has been linked to responses to stimuli such as cocaine, underscoring Arc′s role in activity-dependent gene regulation and potential implications in neurological disorders. Arc monoclonal antibody (C-7) enables researchers to thoroughly investigate the dynamic regulation of Arc protein in various biological contexts, thereby advancing our understanding of neural plasticity and related pathologies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Arc Antibody (C-7) References:

1. Stimulation of neuronal acetylcholine receptors induces rapid gene transcription.  |  Greenberg, ME., et al. 1986. Science. 234: 80-3. PMID: 3749894
2. A critical period for macromolecular synthesis in long-term heterosynaptic facilitation in Aplysia.  |  Montarolo, PG., et al. 1986. Science. 234: 1249-54. PMID: 3775383
3. Activation of arc, a putative 'effector' immediate early gene, by cocaine in rat brain.  |  Fosnaugh, JS., et al. 1995. J Neurochem. 64: 2377-80. PMID: 7722525
4. Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites.  |  Lyford, GL., et al. 1995. Neuron. 14: 433-45. PMID: 7857651

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Arc Antibody (C-7) has 165 citations in a variety of scientific publications.

Primary antibodies like Anti-Arc Antibody (C-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Arc Antibody (C-7) Specifications

Alternate Product Name: ARC

Product Clone Name: C-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-300

Epitope Target: Arc

Epitope Species: human

Product Reactivity/Detection: ARC

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 165 citations in various scientific publications

Available Conjugates/Forms for Arc Antibody (C-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin