ARALAR Antibody (B-2): sc-271056
- ARALAR Antibody (B-2) is a mouse monoclonal IgG2b κ ARALAR antibody, cited in 11 publications, provided at 200 µg/ml
- raised against amino acids 1-67 mapping at the N-terminus of ARALAR of human origin
- ARALAR Antibody (B-2) is recommended for detection of ARALAR of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-ARALAR Antibody (B-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for ARALAR Antibody (B-2) for WB and IHC(P) applications. These reagents are now offered in bundles with ARALAR Antibody (B-2) (see ordering information below).
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ARALAR Antibody (B-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects ARALAR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-ARALAR antibody (B-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ARALAR protein, encoded by the SLC25A12 gene, plays a crucial role in calcium signaling within mitochondria, which is essential for cellular responses to a variety of extracellular stimuli. Specifically, ARALAR functions as a neuronal calcium-binding mitochondrial aspartate-glutamate carrier, facilitating the malate-aspartate NADH shuttle. ARALAR′s calcium-binding domains are oriented towards the extramitochondrial space, allowing for the effective transmission of small calcium signals to mitochondria, which is vital for the synthesis of brain aspartate and N-acetylaspartate, both of which are important for myelin formation. Additionally, ARALAR is implicated in the modulation of mitochondrial NADH levels, which is critical for energy metabolism and cellular signaling. ARALAR expression in brain and skeletal muscle highlights its importance in neurological function and muscle physiology, while ARALAR association with susceptibility to schizophrenia underscores its potential relevance in neuropsychiatric disorders.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
ARALAR Antibody (B-2) References:
- Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier. | Jalil, MA., et al. 2005. J Biol Chem. 280: 31333-9. PMID: 15987682
- Essential role of aralar in the transduction of small Ca2+ signals to neuronal mitochondria. | Pardo, B., et al. 2006. J Biol Chem. 281: 1039-47. PMID: 16269409
- Ca2+ Activation kinetics of the two aspartate-glutamate mitochondrial carriers, aralar and citrin: role in the heart malate-aspartate NADH shuttle. | Contreras, L., et al. 2007. J Biol Chem. 282: 7098-106. PMID: 17213189
- Mitochondrial transporters as novel targets for intracellular calcium signaling. | Satrústegui, J., et al. 2007. Physiol Rev. 87: 29-67. PMID: 17237342
- Role of aralar, the mitochondrial transporter of aspartate-glutamate, in brain N-acetylaspartate formation and Ca(2+) signaling in neuronal mitochondria. | Satrústegui, J., et al. 2007. J Neurosci Res. 85: 3359-66. PMID: 17497669
- Association study of polymorphisms in the mitochondrial aspartate/glutamate carrier SLC25A12 (aralar) gene with schizophrenia. | Hong, CJ., et al. 2007. Prog Neuropsychopharmacol Biol Psychiatry. 31: 1510-3. PMID: 17693006
- Requirement for aralar and its Ca2+-binding sites in Ca2+ signal transduction in mitochondria from INS-1 clonal beta-cells. | Mármol, P., et al. 2009. J Biol Chem. 284: 515-524. PMID: 18996845
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ARALAR Antibody (B-2) | sc-271056 | 200 µg/ml | $316.00 | |||
ARALAR Antibody (B-2): m-IgGκ BP-HRP Bundle | sc-521832 | 200 µg Ab, 40 µg BP | $354.00 | |||
ARALAR Antibody (B-2): m-IgG2b BP-HRP Bundle | sc-548976 | 200 µg Ab; 10 µg BP | $354.00 | |||
ARALAR Antibody (B-2) AC | sc-271056 AC | 500 µg/ml, 25% agarose | $416.00 | |||
ARALAR Antibody (B-2) HRP | sc-271056 HRP | 200 µg/ml | $316.00 | |||
ARALAR Antibody (B-2) FITC | sc-271056 FITC | 200 µg/ml | $330.00 | |||
ARALAR Antibody (B-2) PE | sc-271056 PE | 200 µg/ml | $343.00 | |||
ARALAR Antibody (B-2) Alexa Fluor® 488 | sc-271056 AF488 | 200 µg/ml | $357.00 | |||
ARALAR Antibody (B-2) Alexa Fluor® 546 | sc-271056 AF546 | 200 µg/ml | $357.00 | |||
ARALAR Antibody (B-2) Alexa Fluor® 594 | sc-271056 AF594 | 200 µg/ml | $357.00 | |||
ARALAR Antibody (B-2) Alexa Fluor® 647 | sc-271056 AF647 | 200 µg/ml | $357.00 | |||
ARALAR Antibody (B-2) Alexa Fluor® 680 | sc-271056 AF680 | 200 µg/ml | $357.00 | |||
ARALAR Antibody (B-2) Alexa Fluor® 790 | sc-271056 AF790 | 200 µg/ml | $357.00 |