Aquaporin 7/AQP7 Antibody (D-12): sc-376407
- Aquaporin 7/AQP7 Antibody (D-12) is a mouse monoclonal IgG2a κ Aquaporin 7/AQP7 antibody, cited in 12 publications, provided at 200 µg/ml
- raised against amino acids 169-269 mapping at the C-terminus of AQP7 of rat origin
- Aquaporin 7/AQP7 Antibody (D-12) is recommended for detection of AQP7 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-Aquaporin 7/AQP7 Antibody (D-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgGκ BP-HRP is the preferred secondary detection reagent for Aquaporin 7/AQP7 Antibody (D-12) for WB applications. This reagent is now offered in a bundle with Aquaporin 7/AQP7 Antibody (D-12) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
AQP7 Antibody (D-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects AQP7 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AQP7 (D-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AQP7, also known as aquaporin 7, plays a crucial role in the transport of water, glycerol, and urea across cell membranes, which is particularly important for maintaining osmotic balance and facilitating metabolic processes in adipose tissue. AQP7 is predominantly expressed in adipocytes, where AQP7 is involved in glycerol transport, linking lipid metabolism to energy homeostasis. AQP7′s ability to transport glycerol is especially significant in the context of energy metabolism, as this function allows for the mobilization of fat stores during periods of fasting or increased energy demand. Understanding AQP7′s function and interactions with other proteins can provide insights into metabolic disorders and potential therapeutic targets for obesity and diabetes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Aquaporin 7/AQP7 Antibody (D-12) References:
- The mammalian aquaporin water channel family: A promising new drug target. | Beitz, E. and Schultz, JE. 1999. Curr Med Chem. 6: 457-67. PMID: 10213793
- Localization of aquaporin-7 in rat and mouse kidney using RT-PCR, immunoblotting, and immunocytochemistry. | Nejsum, LN., et al. 2000. Biochem Biophys Res Commun. 277: 164-70. PMID: 11027658
- Expression and localization of aquaporin 7 in normal skeletal myofiber. | Wakayama, Y., et al. 2004. Cell Tissue Res. 316: 123-9. PMID: 14986101
- Expression and immunolocalization of aquaporin-7 in rat gastrointestinal tract. | Laforenza, U., et al. 2005. Biol Cell. 97: 605-13. PMID: 15943587
- Aquaporins 6-12 in the human eye. | Tran, TL., et al. 2013. Acta Ophthalmol. 91: 557-63. PMID: 22974000
- Altered aquaporin expression in glaucoma eyes. | Tran, TL., et al. 2014. APMIS. 122: 772-80. PMID: 24479869
- A Comparison of the Localization of Integral Membrane Proteins in Human and Rabbit Vocal Folds. | Gartling, GJ., et al. 2021. Laryngoscope. 131: E1265-E1271. PMID: 33155693
- Localization of aquaglyceroporins in human and murine white adipose tissue. | Iena, FM., et al. 2022. Histochem Cell Biol. 157: 623-639. PMID: 35235046
- cDNA cloning and gene structure of a novel water channel expressed exclusively in human kidney: evidence for a gene cluster of aquaporins at chromosome locus 12q13. | Ma, T., et al. 1996. Genomics. 35: 543-50. PMID: 8812490
- Molecular cloning and expression of a novel human aquaporin from adipose tissue with glycerol permeability. | Kuriyama, H., et al. 1997. Biochem Biophys Res Commun. 241: 53-8. PMID: 9405233
- Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping. | Ishibashi, K., et al. 1998. Biochim Biophys Acta. 1399: 62-6. PMID: 9714739
- Aquaporins. | Echevarría, M. and Ilundáin, AA. 1998. J Physiol Biochem. 54: 107-18. PMID: 9858131
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Aquaporin 7/AQP7 Antibody (D-12) | sc-376407 | 200 µg/ml | $322.00 | |||
Aquaporin 7/AQP7 Antibody (D-12): m-IgGκ BP-HRP Bundle | sc-522946 | 200 µg Ab, 40 µg BP | $361.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) AC | sc-376407 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) HRP | sc-376407 HRP | 200 µg/ml | $322.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) FITC | sc-376407 FITC | 200 µg/ml | $336.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) PE | sc-376407 PE | 200 µg/ml | $349.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) Alexa Fluor® 488 | sc-376407 AF488 | 200 µg/ml | $364.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) Alexa Fluor® 546 | sc-376407 AF546 | 200 µg/ml | $364.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) Alexa Fluor® 594 | sc-376407 AF594 | 200 µg/ml | $364.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) Alexa Fluor® 647 | sc-376407 AF647 | 200 µg/ml | $364.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) Alexa Fluor® 680 | sc-376407 AF680 | 200 µg/ml | $364.00 | |||
Aquaporin 7/AQP7 Antibody (D-12) Alexa Fluor® 790 | sc-376407 AF790 | 200 µg/ml | $364.00 |