apolipoprotein E/apoE Antibody (A1.4): sc-13521

apoE Antibody (A1.4) is a mouse monoclonal IgG1 kappa light chain antibody that specifically recognizes the apolipoprotein E (apoE) protein, targeting amino acids 126-191 of the human form. Apolipoprotein E is a key protein involved in lipid metabolism, mediating the binding, internalization, and degradation of lipoprotein particles. apoE acts as a ligand for the LDL receptor and the hepatic apoE receptor, playing a vital role in cholesterol transport and homeostasis. This function is critical, as dysregulation of apoE is implicated in a variety of diseases, including cardiovascular conditions like atherosclerosis. apoE exists in several isoforms: E2, E3, and E4, which differ slightly in structure but significantly in function, with E4 notably associated with increased risk for neurodegenerative diseases. Produced in most organs and present in all plasma lipoprotein fractions, apoE contributes to a wide array of physiological processes, including lipid transport, angiogenesis, and cell proliferation. Anti-apoE antibody (A1.4) is recommended for use in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP), making a versatile tool for researchers studying apoE-related pathways.

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apolipoprotein E/apoE Antibody (A1.4) References:

1. Overexpression of apolipoprotein E in transgenic mice: marked reduction in plasma lipoproteins except high density lipoprotein and resistance against diet-induced hypercholesterolemia.  |  Shimano, H., et al. 1992. Proc Natl Acad Sci U S A. 89: 1750-4. PMID: 1542669
2. Apolipoprotein E, Receptors, and Modulation of Alzheimer's Disease.  |  Zhao, N., et al. 2018. Biol Psychiatry. 83: 347-357. PMID: 28434655
3. Apolipoprotein E, periodontal disease and the risk for atherosclerosis: a review.  |  Pereira, LC., et al. 2019. Arch Oral Biol. 98: 204-212. PMID: 30503976
4. Targeting Apolipoprotein E for Alzheimer's Disease: An Industry Perspective.  |  Suidan, GL. and Ramaswamy, G. 2019. Int J Mol Sci. 20: PMID: 31052389
5. Apolipoprotein E Effects on Mammalian Ovarian Steroidogenesis and Human Fertility.  |  Oriá, RB., et al. 2020. Trends Endocrinol Metab. 31: 872-883. PMID: 32684408
6. Apolipoprotein E: cholesterol transport protein with expanding role in cell biology.  |  Mahley, RW. 1988. Science. 240: 622-30. PMID: 3283935
7. Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases.  |  Alagarsamy, J., et al. 2022. Int J Mol Sci. 23: PMID: 36077289
8. Apolipoprotein E in lipid metabolism and neurodegenerative disease.  |  Yang, LG., et al. 2023. Trends Endocrinol Metab. 34: 430-445. PMID: 37357100
9. Genetic heterogeneity of apolipoprotein E and its influence on plasma lipid and lipoprotein levels.  |  de Knijff, P., et al. 1994. Hum Mutat. 4: 178-94. PMID: 7833947
10. Apolipoprotein E: a potent inhibitor of endothelial and tumor cell proliferation.  |  Vogel, T., et al. 1994. J Cell Biochem. 54: 299-308. PMID: 8200910
11. Clearance of postprandial lipoproteins in normolipemics: role of the apolipoprotein E phenotype.  |  Orth, M., et al. 1996. Biochim Biophys Acta. 1303: 22-30. PMID: 8816849
12. Estrogen up-regulates apolipoprotein E (ApoE) gene expression by increasing ApoE mRNA in the translating pool via the estrogen receptor alpha-mediated pathway.  |  Srivastava, RA., et al. 1997. J Biol Chem. 272: 33360-6. PMID: 9407129

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-apolipoprotein E/apoE Antibody (A1.4) has 32 citations in a variety of scientific publications.

Primary antibodies like Anti-apolipoprotein E/apoE Antibody (A1.4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

apolipoprotein E/apoE Antibody (A1.4) Specifications

Alternate Product Name: apolipoprotein E

Product Clone Name: A1.4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 126-191

Epitope Target: apoE

Epitope Species: human

Product Reactivity/Detection: apoE

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 32 citations in various scientific publications

Available Conjugates/Forms for apolipoprotein E/apoE Antibody (A1.4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin