apoA-V Antibody (A-12): sc-393722
- apoA-V Antibody (A-12) is a mouse monoclonal IgG1 κ apoA-V antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 321-336 near the C-terminus of apoA-V of human origin
- apoA-V Antibody (A-12) is recommended for detection of mature apoA-V and apoA-V precursor of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-apoA-V Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for apoA-V Antibody (A-12) for WB applications. These reagents are now offered in bundles with apoA-V Antibody (A-12) (see ordering information below).
apoA-V Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects apoA-V of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). apoA-V (A-12) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. apoA-V, encoded by the human apoA-V gene, consists of 366 amino acids and plays a crucial role in lipid metabolism, particularly in regulating plasma triglyceride levels. apoA-V is primarily synthesized in liver and adipose tissue and secreted into bloodstream, where apoA-V interacts with other apolipoproteins and lipoproteins to modulate lipid transport and metabolism. apoA-V influences triglyceride levels, which are critical for maintaining cardiovascular health, as elevated triglyceride levels are associated with increased risk of cardiovascular diseases. Understanding apoA-V function and interactions with other proteins can provide insights into lipid disorders and potential therapeutic targets for managing dyslipidemia.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
apoA-V Antibody (A-12) References:
- Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar lipoproteins. | Qin, S., et al. 2000. J Lipid Res. 41: 269-76. PMID: 10681411
- Human ApoA-IV overexpression in transgenic mice induces cAMP-stimulated cholesterol efflux from J774 macrophages to whole serum. | Fournier, N., et al. 2000. Arterioscler Thromb Vasc Biol. 20: 1283-92. PMID: 10807744
- GPI-specific phospholipase D associates with an apoA-I- and apoA-IV-containing complex. | Deeg, MA., et al. 2001. J Lipid Res. 42: 442-51. PMID: 11254757
- Butyrate stimulates ApoA-IV-containing lipoprotein secretion in differentiated Caco-2 cells: role in cholesterol efflux. | Nazih, H., et al. J Cell Biochem. 83: 230-8. PMID: 11573240
- Increased plasma apoA-IV level is a marker of abnormal postprandial lipemia: a study in normoponderal and obese subjects. | Vergès, B., et al. 2001. J Lipid Res. 42: 2021-9. PMID: 11734575
- Plasma distribution of apoA-IV in patients with coronary artery disease and healthy controls. | Ezeh, B., et al. 2003. J Lipid Res. 44: 1523-9. PMID: 12777472
- apoA-IV tagged with the ER retention signal KDEL perturbs the intracellular trafficking and secretion of apoB. | Gallagher, JW., et al. 2004. J Lipid Res. 45: 1826-34. PMID: 15258202
- Response of ApoA-IV in pigs to long-term increased dietary oil intake and to the degree of unsaturation of the fatty acids. | Navarro, MA., et al. 2004. Br J Nutr. 92: 763-9. PMID: 15533264
- The apolipoprotein A-I/C-III/A-IV gene cluster: ApoC-III and ApoA-IV expression is regulated by two common enhancers. | Vergnes, L., et al. 1997. Biochim Biophys Acta. 1348: 299-310. PMID: 9366246
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
apoA-V Antibody (A-12) | sc-393722 | 200 µg/ml | $316.00 | |||
apoA-V Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-530557 | 200 µg Ab; 10 µg BP | $354.00 | |||
apoA-V Antibody (A-12): m-IgGκ BP-HRP Bundle | sc-524063 | 200 µg Ab, 40 µg BP | $354.00 | |||
apoA-V Antibody (A-12): m-IgG1 BP-HRP Bundle | sc-544128 | 200 µg Ab; 20 µg BP | $354.00 | |||
apoA-V Antibody (A-12) AC | sc-393722 AC | 500 µg/ml, 25% agarose | $416.00 | |||
apoA-V Antibody (A-12) HRP | sc-393722 HRP | 200 µg/ml | $316.00 | |||
apoA-V Antibody (A-12) FITC | sc-393722 FITC | 200 µg/ml | $330.00 | |||
apoA-V Antibody (A-12) PE | sc-393722 PE | 200 µg/ml | $343.00 | |||
apoA-V Antibody (A-12) Alexa Fluor® 488 | sc-393722 AF488 | 200 µg/ml | $357.00 | |||
apoA-V Antibody (A-12) Alexa Fluor® 546 | sc-393722 AF546 | 200 µg/ml | $357.00 | |||
apoA-V Antibody (A-12) Alexa Fluor® 594 | sc-393722 AF594 | 200 µg/ml | $357.00 | |||
apoA-V Antibody (A-12) Alexa Fluor® 647 | sc-393722 AF647 | 200 µg/ml | $357.00 | |||
apoA-V Antibody (A-12) Alexa Fluor® 680 | sc-393722 AF680 | 200 µg/ml | $357.00 | |||
apoA-V Antibody (A-12) Alexa Fluor® 790 | sc-393722 AF790 | 200 µg/ml | $357.00 | |||
apoA-V (A-12) Neutralizing Peptide | sc-393722 P | 100 µg/0.5 ml | $68.00 |