APIP Antibody (C-9): sc-376666
- APIP Antibody (C-9) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 141-179 within an internal region of APIP of human origin
- recommended for detection of APIP of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine, bovine and porcine
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for APIP Antibody (C-9) for WB applications. These reagents are now offered in bundles with APIP Antibody (C-9) (see ordering information below).
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APIP Antibody (C-9) is a mouse monoclonal IgG1 antibody that detects APIP (Apaf-1-interacting protein) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). APIP is a crucial protein that plays a significant role in cellular protection against ischemic damage, particularly in muscle tissues. APIP functions by suppressing hypoxia-induced cell death, which is vital for maintaining tissue viability during low oxygen conditions. APIP achieves this by activating key signaling pathways involving Akt and ERK 1/2, which inhibit the pro-apoptotic protein caspase-9 through phosphorylation. Additionally, APIP competes with caspase-9 for binding to the caspase recruitment domain of Apaf-1, thereby negatively regulating the activation of caspase-9 and preventing Apaf-1-mediated apoptosis. The significance of APIP in these processes highlights its potential as a therapeutic target in conditions characterized by ischemic injury, making anti-APIP antibody (C-9) an essential tool for researchers studying cell survival mechanisms and apoptosis regulation.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
APIP Antibody (C-9) | sc-376666 | 200 µg/ml | $322.00 | |||
APIP Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-540626 | 200 µg Ab; 10 µg BP | $361.00 | |||
APIP Antibody (C-9): m-IgG1 BP-HRP Bundle | sc-542256 | 200 µg Ab; 20 µg BP | $361.00 | |||
APIP (C-9) Neutralizing Peptide | sc-376666 P | 100 µg/0.5 ml | $69.00 |