APC15 Antibody (H-9): sc-398488

APC15 Antibody (H-9) is a mouse monoclonal IgG2a kappa light chain antibody that detects APC15 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). APC15 (H-9) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. APC15 plays a crucial role in regulating the anaphase-promoting complex/cyclosome (APC/C), which is essential for timely cell cycle progression and proper chromosome segregation during cell division. Dysregulation of APC/C activity, often linked to mutations in APC15, can lead to various forms of cancer due to improper cell cycle control and genomic instability. Understanding APC15 function and interactions within APC/C complex is vital for elucidating tumorigenesis mechanisms and developing targeted therapies. With approximately 135 million base pairs and 1,400 genes, chromosome 11, where APC15 gene is located, is known for dense association with various genetic disorders, highlighting the importance of studying APC15 in both normal cellular function and disease.

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APC15 Antibody (H-9) References:

1. The 11q terminal deletion disorder: a prospective study of 110 cases.  |  Grossfeld, PD., et al. 2004. Am J Med Genet A. 129A: 51-61. PMID: 15266616
2. Human chromosome 11 DNA sequence and analysis including novel gene identification.  |  Taylor, TD., et al. 2006. Nature. 440: 497-500. PMID: 16554811
3. KCNQ1 K+ channel-mediated cardiac channelopathies.  |  Loussouarn, G., et al. 2006. Methods Mol Biol. 337: 167-83. PMID: 16929947
4. Skipping of Exon 1 in the KCNQ1 gene causes Jervell and Lange-Nielsen syndrome.  |  Zehelein, J., et al. 2006. J Biol Chem. 281: 35397-403. PMID: 16987820
5. Beta-thalassaemia and sickle cell anaemia as paradigms of hypercoagulability.  |  Ataga, KI., et al. 2007. Br J Haematol. 139: 3-13. PMID: 17854302
6. The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3.  |  Berger, AC., et al. 2007. J Cell Sci. 120: 3640-52. PMID: 17895371
7. Wilms tumour: prognostic factors, staging, therapy and late effects.  |  Kaste, SC., et al. 2008. Pediatr Radiol. 38: 2-17. PMID: 18026723
8. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks.  |  Lee, JH. and Paull, TT. 2007. Oncogene. 26: 7741-8. PMID: 18066086
9. Targeted cancer therapies based on the inhibition of DNA strand break repair.  |  O'Connor, MJ., et al. 2007. Oncogene. 26: 7816-24. PMID: 18066095
10. APC15 drives the turnover of MCC-CDC20 to make the spindle assembly checkpoint responsive to kinetochore attachment.  |  Mansfeld, J., et al. 2011. Nat Cell Biol. 13: 1234-43. PMID: 21926987
11. APC15 mediates CDC20 autoubiquitylation by APC/C(MCC) and disassembly of the mitotic checkpoint complex.  |  Uzunova, K., et al. 2012. Nat Struct Mol Biol. 19: 1116-23. PMID: 23007861
12. TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC.  |  Kim, DH., et al. 2018. Nat Commun. 9: 4354. PMID: 30341343

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-APC15 Antibody (H-9) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-APC15 Antibody (H-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

APC15 Antibody (H-9) Specifications

Alternate Product Name: APC15

Product Clone Name: H-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-66

Epitope Target: APC15

Epitope Species: human

Product Reactivity/Detection: APC15 of human origin, 3200002M19Rik of mouse origin and the corresponding rat homolog

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine, bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for APC15 Antibody (H-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin