APC Antibody (c-APC 28.9): sc-53166
- APC Antibody (c-APC 28.9) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against human C-terminal APC/MBP fusion protein
- recommended for detection of APC of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See APC (F-3): sc-9998 for APC antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for APC Antibody (c-APC 28.9). This work is in progress.
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SEE ALSO...
APC Antibody (c-APC 28.9) is a mouse monoclonal IgG1 antibody that detects APC in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-APC antibody (c-APC 28.9) targets adenomatous polyposis coli (APC), which plays a crucial role in regulating cell adhesion and maintaining cellular junction integrity. APC (c-APC 28.9) monoclonal antibody recognizes APC protein, consisting of 2,843 amino acids, essential for proper Wnt signaling pathway function, vital for cell proliferation and differentiation. Mutations in APC gene are commonly associated with familial adenomatous polyposis and Gardner′s syndrome, leading to numerous adenomatous polyps that can progress to colon cancer. APC interactions with β-catenin and γ-catenin help regulate cellular adhesion and are involved in adherens junction formation. APC competes with E-cadherin for binding to β- and γ-catenin, and this dynamic maintains cellular architecture and signaling. α-catenin mediates interactions between cytoskeleton and APC-E-cadherin-β/γ-catenin complex, highlighting APC′s importance in cellular structure and function.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
APC Antibody (c-APC 28.9) | sc-53166 | 200 µg/ml | $322.00 |