AP1AR Antibody (C-6): sc-398565
- AP1AR Antibody (C-6) is a mouse monoclonal IgG1 κ AP1AR antibody provided at 200 µg/ml
- raised against amino acids 131-302 mapping at the C-terminus of AP1AR of human origin
- AP1AR Antibody (C-6) is recommended for detection of AP1AR of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-AP1AR Antibody (C-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG1 BP-HRP is the preferred secondary detection reagent for AP1AR Antibody (C-6) for WB applications. This reagent is now offered in a bundle with AP1AR Antibody (C-6) (see ordering information below).
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AP1AR Antibody (C-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects AP1AR protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AP1AR monoclonal antibody (C-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. AP1AR, also known as Gamma-1-adaptin brefeldin A resistance protein or C4orf16, is a crucial 302 amino acid protein that plays a significant role in transport processes between trans-Golgi network and endosomes, which is vital for maintaining cellular homeostasis and protein trafficking. AP1AR regulates membrane association of γ1-Adaptin, a key subunit of c-Fos adapter complex, by interacting through coiled-coil domain with GAE domain of γ1-Adaptin. This interaction facilitates release of c-Fos complex from membranes, thereby influencing various signaling pathways and cellular responses. AP1AR gene is located on human chromosome 4, a region rich in genes and associated with several genetic disorders, including Huntington′s disease and achondroplasia. AP1AR′s role in cellular transport mechanisms underscores potential as a target for research into diseases linked to protein mislocalization and trafficking defects.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
AP1AR Antibody (C-6) References:
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. | Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
- Selective neuronal degeneration in Huntington's disease. | Cowan, CM. and Raymond, LA. 2006. Curr Top Dev Biol. 75: 25-71. PMID: 16984809
- Syndromic craniosynostosis: from history to hydrogen bonds. | Cunningham, ML., et al. 2007. Orthod Craniofac Res. 10: 67-81. PMID: 17552943
- Evc is a positive mediator of Ihh-regulated bone growth that localises at the base of chondrocyte cilia. | Ruiz-Perez, VL., et al. 2007. Development. 134: 2903-12. PMID: 17660199
- Metabolic phenotype of methylmalonic acidemia in mice and humans: the role of skeletal muscle. | Chandler, RJ., et al. 2007. BMC Med Genet. 8: 64. PMID: 17937813
- Muenke syndrome (FGFR3-related craniosynostosis): expansion of the phenotype and review of the literature. | Doherty, ES., et al. 2007. Am J Med Genet A. 143A: 3204-15. PMID: 18000976
- Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias. | de Frutos, CA., et al. 2007. Dev Cell. 13: 872-83. PMID: 18061568
- Regulation of endosomal membrane traffic by a Gadkin/AP-1/kinesin KIF5 complex. | Schmidt, MR., et al. 2009. Proc Natl Acad Sci U S A. 106: 15344-9. PMID: 19706427
- A novel subtype of AP-1-binding motif within the palmitoylated trans-Golgi network/endosomal accessory protein Gadkin/gamma-BAR. | Maritzen, T., et al. 2010. J Biol Chem. 285: 4074-4086. PMID: 19965873
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AP1AR Antibody (C-6) | sc-398565 | 200 µg/ml | $322.00 | |||
AP1AR Antibody (C-6): m-IgG1 BP-HRP Bundle | sc-531767 | 200 µg Ab; 20 µg BP | $361.00 | |||
AP1AR Antibody (C-6) AC | sc-398565 AC | 500 µg/ml, 25% agarose | $424.00 | |||
AP1AR Antibody (C-6) HRP | sc-398565 HRP | 200 µg/ml | $322.00 | |||
AP1AR Antibody (C-6) FITC | sc-398565 FITC | 200 µg/ml | $336.00 | |||
AP1AR Antibody (C-6) PE | sc-398565 PE | 200 µg/ml | $349.00 | |||
AP1AR Antibody (C-6) Alexa Fluor® 488 | sc-398565 AF488 | 200 µg/ml | $364.00 | |||
AP1AR Antibody (C-6) Alexa Fluor® 546 | sc-398565 AF546 | 200 µg/ml | $364.00 | |||
AP1AR Antibody (C-6) Alexa Fluor® 594 | sc-398565 AF594 | 200 µg/ml | $364.00 | |||
AP1AR Antibody (C-6) Alexa Fluor® 647 | sc-398565 AF647 | 200 µg/ml | $364.00 | |||
AP1AR Antibody (C-6) Alexa Fluor® 680 | sc-398565 AF680 | 200 µg/ml | $364.00 | |||
AP1AR Antibody (C-6) Alexa Fluor® 790 | sc-398565 AF790 | 200 µg/ml | $364.00 |