AP-3 sigma Antibody (6): sc-136338

AP-3σ Antibody (6) is a mouse monoclonal IgG1 kappa light chain antibody that detects AP-3 sigma protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AP-3σ (6) antibody is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). AP-3 sigma protein plays a crucial role in the endocytic pathway, specifically in sorting and transport of proteins to lysosomes and other cellular compartments. AP-3 sigma protein is primarily located in the trans-Golgi network and is essential for forming clathrin-coated vesicles, which are vital for receptor-mediated endocytosis. Proper functioning of AP-3 sigma protein is important for maintaining cellular homeostasis and regulating levels of membrane proteins, which can impact various cellular processes, including signal transduction and nutrient uptake. AP-3 sigma protein interacts with other proteins in the AP-3 complex, such as AP-3 delta and AP-3 mu, highlighting AP-3 sigma′s significance in vesicle trafficking and cellular communication.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Contains Mercury: All HRP conjugates (including bundle forms) contain thiomersal, a mercury compound. Do not dispose in trash. Dispose as hazardous chemical waste according to local, state and federal regulations.

Download thiomersal SDS

AP-3 sigma Antibody (6) References:

1. An ear-core interaction regulates the recruitment of the AP-3 complex to membranes.  |  Lefrançois, S., et al. 2004. Dev Cell. 7: 619-25. PMID: 15469849
2. Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes.  |  Coleman, SH., et al. 2005. J Virol. 79: 2066-78. PMID: 15681409
3. AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly.  |  Dong, X., et al. 2005. Cell. 120: 663-74. PMID: 15766529
4. Conservation and diversity in families of coated vesicle adaptins.  |  Ponnambalam, S., et al. 1990. J Biol Chem. 265: 4814-20. PMID: 1969413
5. Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus.  |  Robinson, MS. 1990. J Cell Biol. 111: 2319-26. PMID: 2126014
6. Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2.  |  Kirchhausen, T., et al. 1989. Proc Natl Acad Sci U S A. 86: 2612-6. PMID: 2495531
7. Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation.  |  Jia, GQ., et al. 1996. J Exp Med. 184: 1939-51. PMID: 8920881
8. Characterization of the adaptor-related protein complex, AP-3.  |  Simpson, F., et al. 1997. J Cell Biol. 137: 835-45. PMID: 9151686

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-AP-3σ Antibody (6) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-AP-3σ Antibody (6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

AP-3σ Antibody (6) Specifications

Alternate Product Name: AP-3σ

Product Clone Name: 6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 70-190

Epitope Target: AP-3σ

Epitope Species: mouse

Product Reactivity/Detection: AP-3σ

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for AP-3σ Antibody (6): AC: Agarose, HRP: Horseradish Peroxidase