AP-3σ Antibody (6): sc-136338
- AP-3σ Antibody (6) is a mouse monoclonal IgG1 κ AP-3σ antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 70-190 of AP-3σ of mouse origin
- recommended for detection of AP-3σ of mouse, rat and human origin by WB, IP and IF
- available conjugated to agarose for IP; and to HRP for WB, IHC(P) and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for AP-3σ Antibody (6) for WB applications. These reagents are now offered in bundles with AP-3σ Antibody (6) (see ordering information below).
AP-3σ Antibody (6) is a mouse monoclonal IgG1 kappa light chain antibody that detects AP-3 sigma protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). AP-3σ (6) antibody is available in both non-conjugated and various conjugated forms, including agarose and horseradish peroxidase (HRP). AP-3 sigma protein plays a crucial role in the endocytic pathway, specifically in sorting and transport of proteins to lysosomes and other cellular compartments. AP-3 sigma protein is primarily located in the trans-Golgi network and is essential for forming clathrin-coated vesicles, which are vital for receptor-mediated endocytosis. Proper functioning of AP-3 sigma protein is important for maintaining cellular homeostasis and regulating levels of membrane proteins, which can impact various cellular processes, including signal transduction and nutrient uptake. AP-3 sigma protein interacts with other proteins in the AP-3 complex, such as AP-3 delta and AP-3 mu, highlighting AP-3 sigma′s significance in vesicle trafficking and cellular communication.
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AP-3σ Antibody (6) References:
- An ear-core interaction regulates the recruitment of the AP-3 complex to membranes. | Lefrançois, S., et al. 2004. Dev Cell. 7: 619-25. PMID: 15469849
- Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes. | Coleman, SH., et al. 2005. J Virol. 79: 2066-78. PMID: 15681409
- AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly. | Dong, X., et al. 2005. Cell. 120: 663-74. PMID: 15766529
- Conservation and diversity in families of coated vesicle adaptins. | Ponnambalam, S., et al. 1990. J Biol Chem. 265: 4814-20. PMID: 1969413
- Cloning and expression of gamma-adaptin, a component of clathrin-coated vesicles associated with the Golgi apparatus. | Robinson, MS. 1990. J Cell Biol. 111: 2319-26. PMID: 2126014
- Structural and functional division into two domains of the large (100- to 115-kDa) chains of the clathrin-associated protein complex AP-2. | Kirchhausen, T., et al. 1989. Proc Natl Acad Sci U S A. 86: 2612-6. PMID: 2495531
- Distinct expression and function of the novel mouse chemokine monocyte chemotactic protein-5 in lung allergic inflammation. | Jia, GQ., et al. 1996. J Exp Med. 184: 1939-51. PMID: 8920881
- Characterization of the adaptor-related protein complex, AP-3. | Simpson, F., et al. 1997. J Cell Biol. 137: 835-45. PMID: 9151686
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AP-3σ Antibody (6) | sc-136338 | 200 µg/ml | $322.00 | |||
AP-3σ Antibody (6): m-IgG Fc BP-HRP Bundle | sc-528813 | 200 µg Ab; 10 µg BP | $361.00 | |||
AP-3σ Antibody (6): m-IgGκ BP-HRP Bundle | sc-521357 | 200 µg Ab, 40 µg BP | $361.00 | |||
AP-3σ Antibody (6): m-IgG1 BP-HRP Bundle | sc-543144 | 200 µg Ab; 20 µg BP | $361.00 | |||
AP-3σ Antibody (6) AC | sc-136338 AC | 500 µg/ml, 25% agarose | $424.00 | |||
AP-3σ Antibody (6) HRP | sc-136338 HRP | 200 µg/ml | $322.00 |