AP-2β Antibody (E-8): sc-390281

AP-2β Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects AP-2β protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-AP-2β antibody (E-8) is available as the non-conjugated form. AP-2β protein is a crucial member of the AP-2 transcription factor family, which also includes AP-2α and AP-2γ, and binds to the DNA consensus sequence CCCCAGGC to initiate transcription of specific genes. AP-2β, a splice variant of AP-2α, plays a significant role in regulating gene expression related to developmental processes and cellular differentiation. AP-2β protein is particularly important in breast cancer, as AP-2β protein is involved in upregulating the proto-oncogene c-ErbB-2, which is overexpressed in 25-30% of breast cancer cases. AP-2β protein interaction with other transcription factors, such as the OB2-1 complex, further underscores AP-2β protein importance in gene regulation and cellular signaling pathways. AP-2β protein has been implicated in modulating estrogen receptor expression, highlighting AP-2β protein potential role in hormone-responsive cancers. With applications across western blotting (WB) and immunohistochemistry, AP-2β monoclonal antibody (E-8) serves as an essential tool for researchers studying gene regulation, cancer biology, and developmental processes.

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AP-2β Antibody (E-8) References:

1. The transcription factor AP-2beta causes cell enlargement and insulin resistance in 3T3-L1 adipocytes.  |  Tao, Y., et al. 2006. Endocrinology. 147: 1685-96. PMID: 16373417
2. Association study of the INPP1, 5HTT, BDNF, AP-2beta and GSK-3beta GENE variants and restrospectively scored response to lithium prophylaxis in bipolar disorder.  |  Michelon, L., et al. 2006. Neurosci Lett. 403: 288-93. PMID: 16787706
3. Electrophysiological and behavioral correlates of polymorphisms in the transcription factor AP-2beta coding gene.  |  Hensch, T., et al. 2008. Neurosci Lett. 436: 67-71. PMID: 18358611
4. Transcription factor AP-2beta inhibits glucose-induced insulin secretion in cultured insulin-secreting cell-line.  |  Tsukada, S., et al. 2009. Diabetes Res Clin Pract. 85: 279-85. PMID: 19596470
5. Transcription factor AP-2beta inhibits expression and secretion of leptin, an insulin-sensitizing hormone, in 3T3-L1 adipocytes.  |  Fuke, T., et al. 2010. Int J Obes (Lond). 34: 670-8. PMID: 20065963
6. Transcription factor AP-2beta: a negative regulator of IRS-1 gene expression.  |  Meng, X., et al. 2010. Biochem Biophys Res Commun. 392: 526-32. PMID: 20097161
7. Melatonin inhibits AP-2β/hTERT, NF-κB/COX-2 and Akt/ERK and activates caspase/Cyto C signaling to enhance the antitumor activity of berberine in lung cancer cells.  |  Lu, JJ., et al. 2016. Oncotarget. 7: 2985-3001. PMID: 26672764
8. Conditional deletion of AP-2β in mouse cranial neural crest results in anterior segment dysgenesis and early-onset glaucoma.  |  Martino, VB., et al. 2016. Dis Model Mech. 9: 849-61. PMID: 27483349
9. Targeting NF-κB/AP-2β signaling to enhance antitumor activity of cisplatin by melatonin in hepatocellular carcinoma cells.  |  Hao, J., et al. 2017. Am J Cancer Res. 7: 13-27. PMID: 28123844
10. Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.  |  Moser, M., et al. 1997. Genes Dev. 11: 1938-48. PMID: 9271117

The preferred AP-2β antibody is AP-2β Antibody (C-6): sc-390119.