AOS-1 Antibody (E-12): sc-376628

AOS-1 Antibody (E-12) is a mouse monoclonal IgG2a antibody that detects AOS-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). AOS-1, also known as SUMO-1-activating enzyme or ubiquitin-like 1-activating enzyme E1A, is a crucial component of the ubiquitin-like (UBL) conjugation pathway, specifically functioning as a ubiquitin-activating E1 ligase. AOS-1 plays a vital role in the activation of UBL1, which is essential for various cellular processes, including cell cycle regulation and stress response. AOS-1 operates as a dimeric enzyme, facilitating the ATP-dependent activation of UBL1, and can form heterodimers with UBLE1A and UBLE1B, enhancing functional capacity. Proper functioning of AOS-1 is critical, as disruptions in the UBL conjugation pathway can lead to various diseases, including cancer and neurodegenerative disorders. Through interactions with other proteins in the UBL pathway, AOS-1 serves as a key player in maintaining cellular homeostasis and responding to stress, making AOS-1 an important target for research in cell biology and therapeutic development.

The preferred AOS-1 antibody is AOS-1 Antibody (H-9): sc-398080.