Annexin VIII Antibody (D-1): sc-271577

Annexin VIII Antibody (D-1) is a mouse monoclonal IgG2a kappa light chain antibody designed to detect Annexin VIII, also known as ANXA8, or Annexin A8-like 1 (ANXA8L1), across various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Annexin VIII monoclonal antibody (D-1) is raised against a peptide mapping within amino acids 121-180 of the internal region of human Annexin VIII, ensuring precise and selective binding. Annexin VIII is a member of the annexin family of calcium-binding proteins, which are characterized by a conserved core domain that facilitates phospholipid binding in a calcium-dependent manner. Post-translational modifications of Annexin VIII, such as phosphorylation, play a crucial role in regulating interaction with cellular membranes and other proteins, thereby modulating processes like ion flux, endocytosis, exocytosis, and cellular adhesion. These modifications are essential for maintaining cellular homeostasis and responding to environmental signals, making Annexin VIII a key player in cellular differentiation and signaling pathways. Annexin VIII is predominantly expressed at lower levels compared to Annexin V in most tissues, but shows marked upregulation in acute promyelocytic leukemia (APL) cells, highlighting potential roles in hematopoietic cell differentiation and as a biomarker for certain malignancies. Anti-Annexin VIII antibody (D-1) exhibits high reactivity with Annexin VIII from human origin and shows reactivity with mouse and rat Annexin VIII, providing versatility for studies across different model organisms. Available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, Annexin VIII (D-1) antibody offers flexible options to meet diverse experimental needs.

The preferred Annexin V antibody is Annexin V Antibody (H-3): sc-74438.