Annexin VII Antibody (A-1): sc-17815

Annexin VII Antibody (A-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects Annexin VII protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-Annexin VII antibody (A-1) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Annexin VII, also known as synexin, plays a crucial role in cellular processes by binding to phospholipids in a calcium-dependent manner, which is essential for membrane trafficking and cellular signaling. Annexin VII is primarily located at the plasma membrane in normal muscle tissue, where Annexin VII is involved in the regulation of ion flux and cellular adhesion. In Duchenne′s muscular dystrophy, Annexin VII is released into the cytoplasm and subsequently into the extracellular space, indicating Annexin VII′s potential role in disease progression and muscle degeneration. The annexin family, which includes at least ten mammalian genes, is characterized by a conserved core domain and unique amino terminal regions that may confer binding specificity, highlighting the importance of post-translational modifications for proper sub-cellular localization and function. Annexin VII′s ability to interact with other proteins and involvement in critical cellular processes make Annexin VII a valuable target for research in muscle pathology and related fields.

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Annexin VII Antibody (A-1) References:

1. Annexin VII as a novel marker for invasive phenotype of malignant melanoma.  |  Kataoka, TR., et al. 2000. Jpn J Cancer Res. 91: 75-83. PMID: 10744047
2. Synexin (annexin VII) and membrane fusion during the process of exocytotic secretion.  |  Pollard, HB., et al. 1992. Prog Brain Res. 92: 247-55. PMID: 1284613
3. Knockdown of annexin VII enhances nasopharyngeal carcinoma cell radiosensitivity in vivo and in vitro.  |  Gui, SJ., et al. 2020. Cancer Biomark. 28: 129-139. PMID: 31958076
4. Expression and localization of annexin VII (synexin) in muscle cells.  |  Selbert, S., et al. 1995. J Cell Sci. 108 (Pt 1): 85-95. PMID: 7738119
5. Structural evolution of the annexin supergene family.  |  Smith, PD. and Moss, SE. 1994. Trends Genet. 10: 241-6. PMID: 8091504
6. Annexin VII relocalization as a result of dystrophin deficiency.  |  Selbert, S., et al. 1996. Exp Cell Res. 222: 199-208. PMID: 8549664
7. Calcium-dependent binding of S100C to the N-terminal domain of annexin I.  |  Mailliard, WS., et al. 1996. J Biol Chem. 271: 719-25. PMID: 8557678
8. Functional and genetic analysis of annexin VI.  |  Edwards, HC. and Moss, SE. 1995. Mol Cell Biochem. 149-150: 293-9. PMID: 8569744
9. Annexin II tetramer: structure and function.  |  Waisman, DM. 1995. Mol Cell Biochem. 149-150: 301-22. PMID: 8569746
10. Annexin II in exocytosis: catecholamine secretion requires the translocation of p36 to the subplasmalemmal region in chromaffin cells.  |  Chasserot-Golaz, S., et al. 1996. J Cell Biol. 133: 1217-36. PMID: 8682860
11. Isoform-specific intracellular vesicle formation by recombinant annexin XI-A in Sf9 cells.  |  Sudo, T., et al. 1996. Biochem Biophys Res Commun. 223: 706-11. PMID: 8687461
12. Synexin (annexin VII) hypothesis for Ca2+/GTP-regulated exocytosis.  |  Pollard, HB., et al. 1998. Adv Pharmacol. 42: 81-7. PMID: 9327852

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Annexin VII Antibody (A-1) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-Annexin VII Antibody (A-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Annexin VII Antibody (A-1) Specifications

Alternate Product Name: Annexin VII

Product Clone Name: A-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 9-119

Epitope Target: Annexin VII

Epitope Species: human

Product Reactivity/Detection: Annexin VII

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for Annexin VII Antibody (A-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin